4-(二甲胺基)丁酸 盐酸盐合成路线 （共 9 条）
反应条件
1: 1-methyl-pyrrolidin-2-one With sodium hydroxide in water 10 h; Heating; 2: formaldehyd With formic acid in water 8 h; Heating; 3: With hydrogenchloride in water
参考文献
Cui, Xin; Li, Zhe; Tao, Chuan-Zhou; Xu, Yu; Li, Juan; Liu, Lei; Guo, Qing-Xiang
Organic Letters, 2006 , vol. 8, # 12 p. 2467 - 2470
反应条件
formic acid 16 h; RefluxInert atmosphere;
参考文献
WO2014/18913 A2, ;
Page/Page column 48 ;
反应条件
hydrogenchloride in water 18 h; Reflux;
参考文献
Khan, Gul Shahzada; Dickson, Benjamin D.; Barker, David
Tetrahedron, 2012 , vol. 68, # 6 p. 1790 - 1801
反应条件
1: conc. HCl / 10 h 2: 1.) formic acid, 2.) HCl / H2O / 1.) reflux, 7h, 2.) reflux, 1.5h View Scheme
参考文献
Synthesis, , # 6 p. 468 - 469
反应条件
hydrogenchloride; formic acid in water 1.) reflux, 7h, 2.) reflux, 1.5h; Yield given;
参考文献
Synthesis, , # 6 p. 468 - 469
反应条件
1: (i) SOCl2, (ii) /BRN= 969212/, AlCl3 2: CF3CO2H, H2SO4, CrO3 / aq. acetic acid View Scheme
参考文献
Rueppel,M.L.; Rapoport,H.
Journal of the American Chemical Society, 1972 , vol. 94, p. 3877 - 3883
反应条件
1: NaOH aq. / ethanol / 0 °C / overnight 2: 2.) conc. HCl / 1.) MeOH, 48h, then 50 deg C, 3h View Scheme
参考文献
Andersson, Lars; Kuehler, Thomas; Nilsson, Martin
Synthesis, 1981 , # 6 p. 468 - 469
反应条件
(i) SOCl2, (ii) /BRN= 969212/, AlCl3; Multistep reaction;
参考文献
Rueppel,M.L.; Rapoport,H.
Journal of the American Chemical Society, 1972 , vol. 94, p. 3877 - 3883
反应条件
sodium hydroxide in ethanol
T=0°C; overnight; Yield given;
参考文献
Andersson, Lars; Kuehler, Thomas; Nilsson, Martin
Synthesis, 1981 , # 6 p. 468 - 469
