1-溴-4-(三甲基硅基)苯合成路线 （共 43 条）
参考文献
Chvalovsky, V.; Bazant, V.
Collection of Czechoslovak Chemical Communications, 1951 , vol. 16, p. 580 - 590
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Gmelin Handbook: Si: MVol.C, 22, page 68 - 71
反应条件
1: p-bromophenyl bromide With n-butyllithium in diethyl ether
2: chloro-trimethyl-silane in diethyl ether
Further stages. Title compound not separated from byproducts.;
参考文献
Bo, Zhishan; Schlueter, A. Dieter
Journal of Organic Chemistry, 2002 , vol. 67, # 15 p. 5327 - 5332
参考文献
Chvalovsky; Bazant
Collection of Czechoslovak Chemical Communications, 1951 , vol. 16/17, p. 580,582,585
反应条件
magnesium
folgendes Umsetzen mit Vinylbromid;
参考文献
Kolesnikow; Dawydowa
Zhurnal Obshchei Khimii, 1959 , vol. 29, p. 2042,2044;engl.Ausg.S.2011
反应条件
in tetrahydrofuran; hexane
T=20°C; 2 h;
参考文献
Itami, Kenichiro; Terakawa, Koji; Yoshida, Jun-ichi; Kajimoto, Okitsugu
Journal of the American Chemical Society, 2003 , vol. 125, # 20 p. 6058 - 6059
Title/Abstract Full Text View citing articles Show Details
Itami, Kenichiro; Terakawa, Koji; Yoshida, Jun-Ichi; Kajimoto, Okitsugu
Bulletin of the Chemical Society of Japan, 2004 , vol. 77, # 11 p. 2071 - 2080
反应条件
1.1: Mg; I2 / tetrahydrofuran / 1.5 h / 20 °C
1.2: selenium / tetrahydrofuran / 3 h / 45 °C
1.3: 65 percent / NaBH4 / methanol / 1.5 h / 0 °C
2.1: LDA / tetrahydrofuran / 0.33 h / -78 °C
2.2: 85 percent Turnov. / tetrahydrofuran / 1 h / -78 °C
View Scheme
参考文献
Patra, Pranab K.; Shanmugasundaram, Kandasamy; Matoba, Manabu; Nishide, Kiyoharu; Kajimoto, Tetsuya; Node, Manabu
Synthesis, 2005 , # 3 art. no. F12504SS, p. 447 - 457
反应条件
sodium in diethyl ether; hexane
refluxing for 1 h in Ar-atm.; 12 h at 25°C in Ar-atm.;;
参考文献
Gmelin Handbook: Sn: Org.Verb.2, 1.1.2.1.11.4, page 139 - 145
反应条件
1: 1.) Mg, I2, 2.) dichloro<1,3-bis(diphenylphosphino)propane>nickel(II) / 1.) Et2O, reflux, 3 h, 2.) Et2O, reflux, 2 d
2: 94 percent / ICl / CH2Cl2 / 0.67 h / Ambient temperature
3: 1.) BuLi / 1.) hexane, Et2O, -70 deg C, 1 h, 2.) hexane, Et2O, 20 deg C, 8 h
View Scheme
参考文献
Frahn; Schluter
Synthesis, 1997 , # 11 p. 1301 - 1304
反应条件
n-butyllithium; magnesium sulfate in tetrahydrofuran
n-BuLi added to soln. of BrC6H4SiMe3 in THF at -78°C; after 15 min B(OiPr)3 added dropwise; warmed to room temp. overnight; H2O, Et2O, concd. HCl added; org. phase washed (H2O, brine); solvent removed (vac.); residue dissolved in THF;; neopentyl glycol and MgSO4 added; stirred for 1 h; solvent removed (vac.); hexane added to the oily residue; filtered; crystn. from filtrate at -25°C; elem. anal.;
参考文献
Deeg, Oliver; Baeurle, Peter
Organic and Biomolecular Chemistry, 2003 , vol. 1, # 9 p. 1609 - 1624
反应条件
1.1: n-BuLi / tetrahydrofuran / 0.25 h / -78 °C
1.2: tetrahydrofuran / -78 - 20 °C
2.1: aq. HCl / diethyl ether
3.1: 106 g / MgSO4 / tetrahydrofuran / 1 h
View Scheme
参考文献
Deeg, Oliver; Baeurle, Peter
Organic and Biomolecular Chemistry, 2003 , vol. 1, # 9 p. 1609 - 1624
