1-溴-4-(三甲基硅基)苯合成路线 （共 43 条）
反应条件
1: 1.) Mg, I2, 2.) dichloro<1,3-bis(diphenylphosphino)propane>nickel(II) / 1.) Et2O, reflux, 3 h, 2.) Et2O, reflux, 2 d
2: 94 percent / ICl / CH2Cl2 / 0.67 h / Ambient temperature
View Scheme
参考文献
Frahn; Schluter
Synthesis, 1997 , # 11 p. 1301 - 1304
反应条件
1.1: N,N,N',N'-tetramethylethylenediamine; n-BuLi / diethyl ether / 1 h / -65 °C
1.2: ZnCl2 / diethyl ether; tetrahydrofuran / 1 h / 25 °C
1.3: 32 percent / Pd(PPh3)4 / diethyl ether; tetrahydrofuran / 7 h / 50 °C
2.1: 82 percent / NBS / tetrahydrofuran; acetic acid / 0.5 h / 60 °C
View Scheme
参考文献
Shu, Hotta; Katagiri, Toshifumi
Journal of Heterocyclic Chemistry, 2003 , vol. 40, # 5 p. 845 - 850
反应条件
(i) AlCl3, (ii) /BRN= 2638178/; Multistep reaction;
参考文献
Bhattacharya,S.N. et al.
Journal of the Chemical Society [Section] C: Organic, 1969 , p. 1367 - 1369
