2,3-二氢苯并呋喃-5-乙酸合成路线 （共 7 条）
反应条件
sulfuric acid; water; acetic acid 4 h; Heating;
参考文献
AUSPEX PHARMACEUTICALS, INC.
Patent: US2009/5431 A1, 2009 ;
Location in patent: Page/Page column 31 ;
US 20090005431 A1
参考文献
PFIZER INC.
Patent: WO2006/97848 A1, 2006 ;
Location in patent: Page/Page column 30-31 ;
反应条件
1: 50.3 percent / sulfur, p-toluenesulfonic acid / 5 h / Heating 2: 70 percent / HOAc, H2SO4, H2O / 4 h / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 29, # 11 p. 2326 - 2329
反应条件
N-bromosuccinmide; dibenzoyl peroxide in tetrachloromethane 3 h; Heating / reflux;
参考文献
JANSSEN PHARMACEUTICA, N.V.
Patent: WO2007/75567 A1, 2007 ;
Location in patent: Page/Page column 96 ;
WO 2007/075567 A1
反应条件
1: With borane-THF in tetrahydrofuran T=0 - 20°C; 20 h; 2: With water in tetrahydrofuran
参考文献
ARGENTA DISCOVERY LTD.
Patent: WO2008/96093 A1, 2008 ;
Location in patent: Page/Page column 29 ;
WO 2008/096093 A1
反应条件
sulfuric acid 3 h; Heating / reflux;
参考文献
TEVA PHARMACEUTICAL FINE CHEMICALS S.R.L.; TEVA PHARMACEUTICALS USA, INC.
Patent: WO2007/76157 A2, 2007 ;
Location in patent: Page/Page column 43 ;
反应条件
1: 97 percent / conc. H2SO4 / toluene / 3 h / Heating
2: 56.7 percent / SnCl4 / CH2Cl2 / 2 h / Heating
3: 91 percent / aq. NaOH / methanol / 2 h / Ambient temperature
4: 51.5 percent / NBS, dibenzoyl peroxide / CCl4 / 2 h / Heating
View Scheme
参考文献
Dunn; Ackerman; Tomolonis
Journal of Medicinal Chemistry, 1986 , vol. 29, # 11 p. 2326 - 2329
