3-溴丙酮酸乙酯合成路线

参考文献

Kornacker, Michael G.; Mapelli, Claudio; Riexinger, Douglas James
Patent: US2013/289238 A1, 2013 ;
Location in patent: Page/Page column ;

70-23-53-溴丙酮酸乙酯+

421-52-32,2,2-三氟乙烷硫代酰胺

133046-46-52-三氟甲基-4-羧酸乙酯噻唑

参考文献

MERCK SHARP and DOHME LIMITED
Patent: WO2006/120481 A2, 2006 ;
Location in patent: Page/Page column 19 ;
WO 2006/120481 A2

70-23-53-溴丙酮酸乙酯

111773-24-13-溴-2,2-二氟丙酸乙酯

参考文献

Joyeau, Roger; Molines, Huguette; Labia, Roger; Wakselman, Michel
Journal of Medicinal Chemistry, 1988 , vol. 31, # 2 p. 370 - 374

13515-65-6硫代异丁酰胺+

70-23-53-溴丙酮酸乙酯

133047-44-62-异丙基噻唑-4-羧酸乙酯

参考文献

Kempf, Dale J.; Sham, Hing L.; Marsh, Kennan C.; Flentge, Charles A.; Betebenner, David; Green, Brian E.; McDonald, Edith; Vasavanonda, Sudthida; Saldivar, Ayda; Wideburg, Norman E.; Kati, Warren M.; Ruiz, Lisa; Zhao, Chen; Fino, Lynnmarie; Patterson, Jean; Molla, Akhteruzzaman; Plattner, Jacob J.; Norbeck, Daniel W.
Journal of Medicinal Chemistry, 1998 , vol. 41, # 4 p. 602 - 617

70-23-53-溴丙酮酸乙酯+

53515-17-63-三氟甲基硫代苯甲酰胺

132089-39-5乙基-三氟甲基苯基1,3-噻唑-4-甲酸

参考文献

Takeda Pharmaceutical Company Limited
Patent: EP2264017 A1, 2010 ;
Location in patent: Page/Page column 161-162 ;

70-23-53-溴丙酮酸乙酯+

30761-34-3

30760-79-3

参考文献

Zee-Cheng,K.Y.; Cheng,C.C.
Journal of Heterocyclic Chemistry, 1970 , vol. 7, p. 1439 - 1440

70-23-53-溴丙酮酸乙酯+

30761-30-9

30761-31-0

参考文献

Zee-Cheng,K.Y.; Cheng,C.C.
Journal of Heterocyclic Chemistry, 1970 , vol. 7, p. 1439 - 1440

109-06-82-甲基吡啶+

70-23-53-溴丙酮酸乙酯

3189-48-8

参考文献

Borrows; Holland
Journal of the Chemical Society, 1947 , p. 670

70-23-53-溴丙酮酸乙酯+

64559-06-43-甲氧基苯硫代甲酰胺

115299-08-6

参考文献

Zia, Mehwash; Akhtar, Tashfeen; Hameed, Shahid; Al-Masoudi, Najim A.
Zeitschrift fur Naturforschung - Section B Journal of Chemical Sciences, 2012 , vol. 67, # 7 p. 747 - 758

60-35-5乙酰胺+

70-23-53-溴丙酮酸乙酯

10200-43-82-甲基-4-恶唑甲酸乙酯

参考文献

Takeda Chemical Industries, Ltd.
Patent: EP1186604 A1, 2002 ;
Location in patent: Page 109-110 ;
EP 1186604 A1