3-溴丙酮酸乙酯合成路线

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Rzasa, Robert M.; Kaller, Matthew R.; Liu, Gang; Magal, Ella; Nguyen, Thomas T.; Osslund, Timothy D.; Powers, David; Santora, Vincent J.; Viswanadhan, Vellarkad N.; Wang, Hui-Ling; Xiong, Xiaoling; Zhong, Wenge; Norman, Mark H.
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70-23-53-溴丙酮酸乙酯

181633-60-32-甲酰基噁唑-4-羧酸乙酯

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Actelion Pharmaceuticals Ltd.
Patent: US2012/115916 A1, 2012 ;

214834-18-1N－Boc-4-硫代甲酰胺+

70-23-53-溴丙酮酸乙酯

365413-31-64-[4-(乙氧羰酰)-1,3-噻唑-2-YL]四氢-1(2H)-吡啶羧酸叔丁酯

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METRIS THERAPEUTICS LIMITED
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70-23-53-溴丙酮酸乙酯

365413-31-64-[4-(乙氧羰酰)-1,3-噻唑-2-YL]四氢-1(2H)-吡啶羧酸叔丁酯

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Merck Patent Gesellschaft Mit Beschrankter Haftling
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70-23-53-溴丙酮酸乙酯+

79456-26-12-氨基-3-氯-5-三氟甲基吡啶

353258-31-88-氯-6-(三氟甲基)咪唑并[1,2-a]-吡啶-2-羧酸乙酯

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EXELIXIS, INC.; CANNE BANNEN, Lynne; CHAN, Diva Sze-ming; GU, Xiao-hui; MAC, Morrison, B.; NG, Stephanie; WANG, Tie-lin; WANG, Yong; XU, Wei
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Sawai Pharmaceutical Co., Ltd.
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70-23-53-溴丙酮酸乙酯+

141-97-9乙酰乙酸乙酯

29172-17-6

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Lyalin, V.V.; Grigorash, R.V.; Alekseeva, L.A.; Yagupol'skii, L.M.
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2227-62-53-溴硫代苯甲酰胺+

70-23-53-溴丙酮酸乙酯

786654-97-52-(3-溴苯基)-噻唑-4-羧酸乙酯

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THE INSTITUTES FOR PHARMACEUTICAL DISCOVERY, LLC
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WO 2008/033934 A1

108-48-52,6-二甲基吡啶+

70-23-53-溴丙酮酸乙酯

288-47-1噻唑

参考文献

Kalesse, Markus; Bülow, Leíla; Rentsch, Andreas; Girbig, Anna-Katharina; Eggert, Ulrike; Malek, Nisar; Frank, Ronald; Brodmann, Tobias
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70-23-53-溴丙酮酸乙酯+

27366-72-9二甲胺基硫代乙酰胺盐酸盐

82586-66-12-(二甲基氨基甲基)-4-噻唑羧酸乙酯

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Eli Lilly and Company
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