(6CI,7CI,8CI,9CI)-4-甲基喹唑啉合成路线 （共 35 条）
反应条件
ammonium acetate
T=137°C; 3 h;
参考文献
Uff, Barrie C.; Joshi, Bijaya L.; Popp, Frank D.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1986 , p. 2295 - 2304
反应条件
sodium hydroxide in ethanol
Heatingconc. HCl, MeOH, reflux;
参考文献
Singh, Harjit; Aggarwal, Sunil K.; Malhotra, Nageshwar
Tetrahedron, 1986 , vol. 42, # 4 p. 1139 - 1144
反应条件
1: 69 percent / aluminum chloride / CH2Cl2 / 48 h / Ambient temperature
2: 72 percent / sodium hydride, DMF / 3 h / Ambient temperature
3: 9 percent / benzoic acid / Heating; base hydrolysis, various reagents
View Scheme
参考文献
Hahn, Jung-Tai; Popp, Frank D.
Journal of Heterocyclic Chemistry, 1989 , vol. 26, p. 1357 - 1372
反应条件
1: 36 percent / sodium hydride (50percent) / dimethylformamide / 0.5 h
2: 63 percent / NaOH (10percent) / methanol / 0.5 h
View Scheme
参考文献
Higashino, Takeo; Kokubo, Hiroyasu; Hayashi, Eisaku
Chemical & Pharmaceutical Bulletin, 1985 , vol. 33, # 3 p. 950 - 961
反应条件
1: zinc oxide / toluene / 7 h / 80 °C
2: ammonium hydroxide / isopropyl alcohol / 10 h / 90 °C / |Sealed tube
View Scheme
参考文献
Zhao, Dan; Zhu, Min-Xue; Wang, Yue; Shen, Qi; Li, Jian-Xin
Organic and Biomolecular Chemistry, 2013 , vol. 11, # 37 p. 6246 - 6249
反应条件
1: 50percent sodium hydride in oil / dimethylformamide / 2 h / Ambient temperature
2: 57 percent / AlCl3 / CH2Cl2 / 48 h / Ambient temperature
3: 50percent sodium hydride in oil dispersion / dimethylformamide / 3 h
4: 40percent potassium hydroxide / ethanol; H2O / Heating
View Scheme
参考文献
Kant, Joydeep; Popp, Frank D.; Uff, Barrie C.
Journal of Heterocyclic Chemistry, 1985 , vol. 22, p. 1313 - 1316
参考文献
Elderfield; Serlin
Journal of Organic Chemistry, 1951 , vol. 16, p. 1669,1680
反应条件
potassium hydroxide in ethanol; water
Heating; Yield given;
参考文献
Kant, Joydeep; Popp, Frank D.; Uff, Barrie C.
Journal of Heterocyclic Chemistry, 1985 , vol. 22, p. 1313 - 1316
反应条件
1: 50 percent / sodium hydride, DMF / Ambient temperature
2: 21 percent / benzoic acid / various solvent(s) / 208 - 210 °C
View Scheme
参考文献
Hahn, Jung-Tai; Popp, Frank D.
Journal of Heterocyclic Chemistry, 1989 , vol. 26, p. 1357 - 1372
反应条件
1: 61 percent / sodium hydride, DMF / Ambient temperature
2: 7 percent / benzoic acid / xylene / 139 °C
View Scheme
参考文献
Hahn, Jung-Tai; Popp, Frank D.
Journal of Heterocyclic Chemistry, 1989 , vol. 26, p. 1357 - 1372
