反应条件
1: 100 percent / pyridine / CH2Cl2 / 2 h / Ambient temperature 2: 89 percent / Et3N / tetrahydrofuran / 0.25 h 3: 90 percent / LiOH / H2O; dioxane / 18 h / Ambient temperature 4: 1.) 1-hydroxybenzotriazole hydrate, N,N'-dicyclohexylcarbodiimide / 1.) EtOAc, RT, 2 h, 2.) 18 h 5: 89 percent / H2 / Pearlman's catalyst / ethanol / 18 h / 25 °C / 2327.2 Torr 6: 80 percent / ethyl acetate / 24 h / Ambient temperature View Scheme
参考文献
Horwell, David C.; Hughes, John; Hunter, John C.; Pritchard, Martyn C.; Richardson, Reginald S.; at al.
Journal of Medicinal Chemistry, 1991 , vol. 34, # 1 p. 404 - 414
