2-氨基-2-苯基乙酰胺合成路线 （共 68 条）
反应条件
recombinant Rhodopseudomonas palustris HaA2 nitrile hydratase; water T=5°C; pH=5; citrate buffer; enantioselective reaction;
参考文献
Organic and Biomolecular Chemistry, , vol. 9, # 8 p. 3011 - 3019
反应条件
1: (R)-1,1'-binaphthyl-3,3'-bis(Ph2P=O)-2,2'-diyl-AlCl; PhOH / CH2Cl2 / 44 h / -40 °C 2: 90 percent / HCOOH; HCl(gas) / 1 h / 20 °C 3: DDQ / tetrahydrofuran / 1 h / 3 °C 4: 1 N aq. HCl / tetrahydrofuran / 3 - 20 °C View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 48, # 10 p. 1586 - 1592
反应条件
1: molecular sieves 4A / toluene / 1 h / 20 °C 2: (R)-1,1'-binaphthyl-3,3'-bis(Ph2P=O)-2,2'-diyl-AlCl; PhOH / CH2Cl2 / 44 h / -40 °C 3: 90 percent / HCOOH; HCl(gas) / 1 h / 20 °C 4: DDQ / tetrahydrofuran / 1 h / 3 °C 5: 1 N aq. HCl / tetrahydrofuran / 3 - 20 °C View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 48, # 10 p. 1586 - 1592
反应条件
1: 90 percent / HCOOH; HCl(gas) / 1 h / 20 °C 2: DDQ / tetrahydrofuran / 1 h / 3 °C 3: 1 N aq. HCl / tetrahydrofuran / 3 - 20 °C View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 48, # 10 p. 1586 - 1592
反应条件
phosphate buffer; Pantoea endophytica 26.2.2 permeabilized cells T=28°C; pH=7.4; 0.5 h;
参考文献
Tetrahedron Asymmetry, , vol. 13, # 24 p. 2629 - 2633
反应条件
1: 90 percent / HCl; HCO2H / 1 h / 20 °C 2: 91 percent / DDQ / tetrahydrofuran / 1 h / 3 °C View Scheme
参考文献
Angewandte Chemie (International Edition in English), , vol. 39, # 9 p. X1650-1652
反应条件
1: 26 percent / methanol / 24 h / Heating 2: hydrochloric acid / formic acid / 18 h View Scheme
参考文献
Bulletin de la Societe Chimique de France, , vol. 130, p. 513 - 520
反应条件
1: 92 percent / thionyl chloride / 3 h / Heating 2: 80 percent / NH3 / methanol View Scheme
参考文献
Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), , # 8 p. 1279 - 1285
反应条件
hydrogenchloride in formic acid 18 h;
参考文献
Bulletin de la Societe Chimique de France, , vol. 130, p. 513 - 520
反应条件
Rhodococcus sp. AJ270 in phosphate buffer T=30°C; pH=7.62; 2 h; Title compound not separated from byproducts;
参考文献
Tetrahedron Letters, , vol. 42, # 39 p. 6925 - 6927
