2-氨基-2-苯基乙酰胺合成路线 （共 68 条）
反应条件
1.1: hydrogenchloride / 1,4-dioxane; methanol 2.1: water; methanol / 20 h / 40 °C / Sealed tube 3.1: sulfuric acid / dichloromethane; water / 3.25 h / -10 - 0 °C / Cooling with ice 3.2: pH 8 - 9 4.1: ammonium formate / palladium on carbon / isopropyl alcohol / 1 h / Inert atmosphere; Reflux View Scheme
反应条件
sodium hydroxide in methanol; water T=-20°C; 2 h; Yield given;
参考文献
Baertschi; Dorman; Occolowitz; Spangle; Collins; Wildfeuer; Lorenz
Journal of Pharmaceutical Sciences, 1993 , vol. 82, # 6 p. 622 - 626
反应条件
penicillin acylasefrom Escherichia coli; water
参考文献
Brugging, Alle; Roos, Eric C.; De Vroom, Erik
Organic Process Research and Development, 1998 , vol. 2, # 2 p. 128 - 133
反应条件
1: 1.) 2N NaOH; 2.) 2N NaOH / 1.) r.t., 4 h; 2.) r.t., overnight
2: aq. NH3 / 1 h / Ambient temperature
View Scheme
参考文献
Oya; Matsumoto; Takashina; Iwao; Funae
Chemical and Pharmaceutical Bulletin, 1981 , vol. 29, # 1 p. 63 - 70
参考文献
McKenzie; Wood
Chemische Berichte, 1938 , vol. 71, p. 358,364
反应条件
lithium aluminium tetrahydride; diethyl ether
参考文献
AGIOS PHARMACEUTICALS, INC.; CAO, Sheldon; POPOVICI-MULLER, Janeta; SALITURO, Francesco G.; SAUNDERS, Jeffrey; TAN, Xuefei; TRAVINS, Jeremy; YAN, Shunqi; YE, Zhixiong
Patent: WO2012/171506 A1, 2012 ;
Location in patent: Page/Page column 115 ;
WO 2012/171506 A1
反应条件
1: 96 percent / potassium carbonate / ethanol / Heating
2: 64 percent / tosyl chloride; pyridine / CH2Cl2
View Scheme
参考文献
Beaufort-Droal, Virginie; Pereira, Elisabeth; Thery, Vincent; Aitken, David J.
Tetrahedron, 2006 , vol. 62, # 51 p. 11948 - 11954
参考文献
Tiemann; Friedlaender
Chemische Berichte, 1881 , vol. 14, p. 1967
