5-苯基-3,4-二氢-2H-吡咯合成路线 （共 67 条）
反应条件
1: tributyl-amine; trichlorophosphate / Reflux
2: tetrahydrofuran / 13 h / 0 - 20 °C
3: sodium iodide / acetone / 19 h / 20 °C / Inert atmosphere
4: water; lithium chloride / dimethyl sulfoxide / 12 h / 100 - 110 °C
View Scheme
参考文献
More, Satish S.; Mohan, T. Krishna; Kumar, Y. Sateesh; Kumar, U.K. Syam; Patel, Navin B.
Beilstein Journal of Organic Chemistry, 2011 , vol. 7, p. 831 - 838
反应条件
1: tetrahydrofuran / 13 h / 0 - 20 °C
2: sodium iodide / acetone / 19 h / 20 °C / Inert atmosphere
3: water; lithium chloride / dimethyl sulfoxide / 12 h / 100 - 110 °C
View Scheme
参考文献
More, Satish S.; Mohan, T. Krishna; Kumar, Y. Sateesh; Kumar, U.K. Syam; Patel, Navin B.
Beilstein Journal of Organic Chemistry, 2011 , vol. 7, p. 831 - 838
反应条件
1: triethylamine; magnesium chloride / acetonitrile / 0 - 20 °C
2: tributyl-amine; trichlorophosphate / Reflux
3: tetrahydrofuran / 13 h / 0 - 20 °C
4: sodium iodide / acetone / 19 h / 20 °C / Inert atmosphere
5: water; lithium chloride / dimethyl sulfoxide / 12 h / 100 - 110 °C
View Scheme
参考文献
More, Satish S.; Mohan, T. Krishna; Kumar, Y. Sateesh; Kumar, U.K. Syam; Patel, Navin B.
Beilstein Journal of Organic Chemistry, 2011 , vol. 7, p. 831 - 838
反应条件
1.1: isopropylmagnesium chloride / tetrahydrofuran / 1.33 h / -25 °C
1.2: 1.33 h / -75 °C
2.1: dichloromethane / 48 h / 20 °C
View Scheme
参考文献
Sun, Xiaowei; Gao, Chengzhe; Zhang, Fan; Song, Zhuang; Kong, Lingyi; Wen, Xiaoan; Sun, Hongbin
Tetrahedron, 2014 , vol. 70, # 3 p. 643 - 649
反应条件
sodium hydroxide; trifluoroacetic acid
1.) RT, 3 h, 2.) 0 deg C; Yield given. Multistep reaction;
参考文献
Giovannini, Arianna; Savoia, Diego; Umani-Ronchi, Achille
Journal of Organic Chemistry, 1989 , vol. 54, # 1 p. 228 - 234
反应条件
triethylsilane; trifluoroacetic acid
参考文献
Brinner, Kristin M.; Ellman, Jonathan A.
Organic and Biomolecular Chemistry, 2005 , vol. 3, # 11 p. 2109 - 2113
反应条件
n-butyllithium
1.) THF; Yield given. Multistep reaction;
参考文献
Feringa, Ben L.; Jansen, F. G. A.
Tetrahedron Letters, 1986 , vol. 27, # 4 p. 507 - 508
反应条件
iodine; magnesium
1.) Et2O, reflux, 1 h, 2.) THF, room temperature, 15 h; Yield given. Multistep reaction;
参考文献
Keppens, Marian; De Kimpe, Norbert; Fonck, Gwendolien
Synthetic Communications, 1996 , vol. 26, # 16 p. 3097 - 3102
反应条件
chloro-trimethyl-silane
Inert atmosphere;
参考文献
Huang, Weizhou; Ni, Chuanfa; Zhao, Yanchuan; Zhang, Wei; Dilman, Alexander D.; Hu, Jinbo
Tetrahedron, 2012 , vol. 68, # 26 p. 5137 - 5144
反应条件
in acetonitrile
UV-irradiationInert atmosphere;
参考文献
Suyama, Kanji; Inoue, Tomohiro; Shirai, Masamitsu
Chemistry Letters, 2010 , vol. 39, # 4 p. 362 - 363
