1,2-二氢-6-甲基-3-硝基-2-氧代-4-吡啶羧酸乙酯合成路线 （共 5 条）
反应条件
1: 95 percent / CH2Cl2 / Heating 2: Dibal-H / CH2Cl2 3: (COCl)2; DMSO; Et3N View Scheme
参考文献
Coburn, Craig A.; Rush, Diane M.; Williams, Peter D.; Homnick, Carl; Lyle, Elizabeth A.; Lewis, S. Dale; Lucas Jr., Bobby J.; Di Muzio-Mower, Jillian M.; Juliano, Marylou; Krueger, Julie A.; Vastag, Kari; Chen, I-Wu; Vacca, Joseph P.
Bioorganic and Medicinal Chemistry Letters, 2000 , vol. 10, # 10 p. 1069 - 1072
反应条件
piperidinium acetate in water
T=40°C; 16 h;
参考文献
Merck and Co., Inc.
Patent: US6350745 B1, 2002 ;
Location in patent: Page column 17 ;
US 6350745 B1
反应条件
piperidinium acetate in water
Condensation; Heating;
参考文献
Coburn, Craig A.; Rush, Diane M.; Williams, Peter D.; Homnick, Carl; Lyle, Elizabeth A.; Lewis, S. Dale; Lucas Jr., Bobby J.; Di Muzio-Mower, Jillian M.; Juliano, Marylou; Krueger, Julie A.; Vastag, Kari; Chen, I-Wu; Vacca, Joseph P.
Bioorganic and Medicinal Chemistry Letters, 2000 , vol. 10, # 10 p. 1069 - 1072
反应条件
trimethyl-oxonium tetrafluoroborate in dichloromethane
T=40°C; 24 - 72 h;
参考文献
Merck and Co., Inc.
Patent: US6350745 B1, 2002 ;
Location in patent: Page column 18 ;
US 6350745 B1
反应条件
in dichloromethane
protection; Heating;
参考文献
Coburn, Craig A.; Rush, Diane M.; Williams, Peter D.; Homnick, Carl; Lyle, Elizabeth A.; Lewis, S. Dale; Lucas Jr., Bobby J.; Di Muzio-Mower, Jillian M.; Juliano, Marylou; Krueger, Julie A.; Vastag, Kari; Chen, I-Wu; Vacca, Joseph P.
Bioorganic and Medicinal Chemistry Letters, 2000 , vol. 10, # 10 p. 1069 - 1072
