5,5-双(4-氟苯基)咪唑烷-2,4-二酮合成路线 （共 4 条）
反应条件
potassium hydroxide in ethanol
T=50 - 60°C; 2 h;
参考文献
Page; Graham; Park
Tetrahedron, 1992 , vol. 48, # 35 p. 7265 - 7274
反应条件
trifluorormethanesulfonic acid
T=100°C; 2 h;
参考文献
Klumpp, Douglas A.; Yeung, Ka Yeun; Prakash, G. K. Surya; Olah, George A.
Synlett, 1998 , # 8 p. 918 - 920
反应条件
1: KOH / ethanol / 2 h / Heating
2: AcOH
View Scheme
参考文献
Kanyonyo, Martial; Govaerts, Sophie J.; Hermans, Emmanuel; Poupaert, Jacques H.; Lambert, Didier M.
Bioorganic and Medicinal Chemistry Letters, 1999 , vol. 9, # 15 p. 2233 - 2236
反应条件
1: 85 percent / N-bromosuccinimide / acetone; H2O / 0.5 h / 5 deg C to r.t.
2: 83 percent / KOH / ethanol / 2 h / 50 - 60 °C
View Scheme
参考文献
Page; Graham; Park
Tetrahedron, 1992 , vol. 48, # 35 p. 7265 - 7274
