二乙基[[(3-氯-4-氟苯基)氨基]亚甲基]丙二酸酯合成路线 （共 12 条）
反应条件
1: diphenyl ether / 1 h / Heating
2: 90 percent / K2CO3 / dimethylformamide / 10 h / 80 - 90 °C
3: 90 percent / 2N NaOH / 2 h / Heating
4: 66 percent / 5 h / 130 - 140 °C
5: 89 percent / Et3N / dimethylformamide / 2 h / 80 - 90 °C
View Scheme
参考文献
Koga, Hiroshi; Itoh, Akira; Murayama, Satoshi; Suzue, Seigo; Irikura, Tsutomu
Journal of Medicinal Chemistry, 1980 , vol. 23, # 12 p. 1358 - 1363
反应条件
1: diphenyl ether / 1 h / Heating
2: 90 percent / K2CO3 / dimethylformamide / 10 h / 80 - 90 °C
3: 90 percent / 2N NaOH / 2 h / Heating
4: 66 percent / 5 h / 130 - 140 °C
5: 97 percent / Et3N / 90 - 100 °C
View Scheme
参考文献
Koga, Hiroshi; Itoh, Akira; Murayama, Satoshi; Suzue, Seigo; Irikura, Tsutomu
Journal of Medicinal Chemistry, 1980 , vol. 23, # 12 p. 1358 - 1363
