(6R,7S)-7-[(溴乙酰)氨基]-7-甲氧基-3-[[(1-甲基-1H-四唑-5-基)硫]甲基]-8-氧代-5-硫杂-1-氮杂双环[4.2.0]辛-2-烯-2-甲酸二苯甲基酯合成路线 （共 3 条）
反应条件
1: With pyridine in dichloromethane T=-30 - -20°C; 1 h; 2: With N-bromosuccinmide in methanol; dichloromethane T=0 - 5°C; 1 h;
参考文献
US2007/93657 A1, ;
Page/Page column 1 ;
反应条件
1: With bromine in dichloromethane T=0 - 5°C; 2 h; 2: With sodium thiosulfate in dichloromethane; water 3: in methanol T=20°C; 0.5 h; Purification / work up;
参考文献
EP1777228 A1, ;
Page/Page column 3 ;
反应条件
1: (6R-cis)-7-amino-3-lt;lt;(1-methyl-1H-tetrazol-5-yl)thiogt;methylgt;-7-(methylthio)-8-oxo-5-thia-1-azabicyclolt;4.2.0gt;oct-2-ene-2-carboxylic acid diphenylmethyl ester; diphenylmethyl (6R,7S)-7-amino-7-methoxy-3-lt;lt;(1-methyl-1H-tetrazol-5-yl)thiogt;methylgt;-Δ3-cephem-4-carboxylate; 2-bromo acetyl bromide With pyridine in dichloromethane T=-30 - -20°C; 1 h; 2: in dichloromethane; water T=0 - 5°C; 3: methanol With N-bromosuccinmide; sodium thiosulfate Purification / work up; more than 3 stages;
参考文献
EP1777228 A1, ;
Page/Page column 2 ;
