5-氟-1-苯并噻吩-2-羧酸合成路线 （共 4 条）
反应条件
potassium hydroxide in ethanol; water 1.5 h; Heating;
参考文献
Matsunaga, Nobuyuki; Kaku, Tomohiro; Itoh, Fumio; Tanaka, Toshimasa; Hara, Takahito; Miki, Hiroshi; Iwasaki, Masahiko; Aono, Tetsuya; Yamaoka, Masuo; Kusaka, Masami; Tasaka, Akihiro
Bioorganic and medicinal chemistry, 2004 , vol. 12, # 9 p. 2251 - 2273
反应条件
1: 53 percent / potassium carbonate / dimethylformamide / 20 h / 20 - 60 °C 2: 99 percent / KOH / ethanol; H2O / 1.5 h / Heating View Scheme
参考文献
Bioorganic and medicinal chemistry, , vol. 12, # 9 p. 2251 - 2273
反应条件
quinoline; copper T=185°C; 2 h;
参考文献
Matsunaga, Nobuyuki; Kaku, Tomohiro; Itoh, Fumio; Tanaka, Toshimasa; Hara, Takahito; Miki, Hiroshi; Iwasaki, Masahiko; Aono, Tetsuya; Yamaoka, Masuo; Kusaka, Masami; Tasaka, Akihiro
Bioorganic and medicinal chemistry, 2004 , vol. 12, # 9 p. 2251 - 2273
反应条件
1.1: 92 percent / copper; quinoline / 2 h / 185 °C 2.1: n-BuLi / tetrahydrofuran; hexane / 1 h / -78 °C 2.2: 99 percent / tetrahydrofuran; hexane / 1 h / -78 °C View Scheme
参考文献
Matsunaga, Nobuyuki; Kaku, Tomohiro; Itoh, Fumio; Tanaka, Toshimasa; Hara, Takahito; Miki, Hiroshi; Iwasaki, Masahiko; Aono, Tetsuya; Yamaoka, Masuo; Kusaka, Masami; Tasaka, Akihiro
Bioorganic and medicinal chemistry, 2004 , vol. 12, # 9 p. 2251 - 2273
