4-甲基-3,4-二氢-2H-异喹啉-1-酮合成路线 （共 7 条）
反应条件
lithium aluminium tetrahydride in tetrahydrofuran 24 h; Heating;
参考文献
Grunewald; Sall; Monn
Journal of Medicinal Chemistry, 1988 , vol. 31, # 2 p. 433 - 444
反应条件
trifluorormethanesulfonic acid
T=0 - 70°C; 19 h;
参考文献
Kurouchi, Hiroaki; Kawamoto, Kyoko; Sugimoto, Hiromichi; Nakamura, Satoshi; Otani, Yuko; Ohwada, Tomohiko
Journal of Organic Chemistry, 2012 , vol. 77, # 20 p. 9313 - 9328,16
反应条件
trifluorormethanesulfonic acid in dichloromethane
T=50°C; 12 h; Inert atmosphere;
参考文献
Raja, Erum K.; Nilsson Lill, Sten O.; Klumpp, Douglas A.
Chemical Communications, 2012 , vol. 48, # 65 p. 8141 - 8143
反应条件
1: 77.6 percent / Et3N / tetrahydrofuran / 24 h / Ambient temperature
2: 64.3 percent / polyphosphoric acid / 0.33 h / 140 °C
View Scheme
参考文献
Canfield, Lesley M.; Crabb, Trevor A.
Journal of Chemical Research, Miniprint, 1997 , # 11 p. 2401 - 2416
反应条件
in ethanol
T=28°C; 72 h; culture of fungus Cunninghamella elegans Lendner;
参考文献
Canfield, Lesley M.; Crabb, Trevor A.
Journal of Chemical Research, Miniprint, 1997 , # 11 p. 2401 - 2416
反应条件
1: 97.6 percent / 10percent aq. NaOH
2: 5.2 percent / ethanol / 72 h / 28 °C / culture of fungus Cunninghamella elegans Lendner
View Scheme
参考文献
Canfield, Lesley M.; Crabb, Trevor A.
Journal of Chemical Research, Miniprint, 1997 , # 11 p. 2401 - 2416
反应条件
PPA
T=115°C; 2.5 h; other time, temperature; Product distribution;
参考文献
Potapov, V.M.; Dem'yanovich, V. M.; Vendrova, O. E.; Khlebnikov, V. A.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1983 , vol. 19, # 5 p. 528 - 533
Khimiya Geterotsiklicheskikh Soedinenii, 1983 , vol. 19, # 5 p. 655 - 660
