7-二甲基氨基-4-甲基香豆素-3-异硫氰酸酯合成路线 （共 9 条）
反应条件
in DMF (N,N-dimethyl-formamide) 0.5 h;
参考文献
WO2004/48386 A2, ;
Page 75 ;
WO 2004/048386 A2
反应条件
in N,N-dimethyl-formamide
参考文献
US2004/242883 A1, ;
US 20040242883 A1
反应条件
2,4,6-trichloro-1,3,5-triazine in N,N-dimethyl-formamide 0.5 h;
参考文献
Boschelli, Diane H.; Wu, Biqi; Sosa, Ana Carolina Barrios; Durutlic, Haris; Ye, Fei; Raifeld, Yuri; Golas, Jennifer M.; Boschelli, Frank
Journal of Medicinal Chemistry, 2004 , vol. 47, # 27 p. 6666 - 6668
反应条件
1: 2.47 g / aq. NaOH / ethanol / 1 h / Heating 2: thionyl chloride / 2 h / Heating 3: 10.9 g / aq. ammonia / acetone / 10 °C 4: 9.0 g / cyanuric chloride / dimethylformamide / 0.5 h View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 47, # 27 p. 6666 - 6668
反应条件
1: thionyl chloride / 2 h / Heating 2: 10.9 g / aq. ammonia / acetone / 10 °C 3: 9.0 g / cyanuric chloride / dimethylformamide / 0.5 h View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 47, # 27 p. 6666 - 6668
反应条件
1: With lithium diisopropyl amide in tetrahydrofuran; n-heptane; ethylbenzene
T=-78°C; 0.333333 h;
2: With iodine in tetrahydrofuran; n-heptane; ethylbenzene
T=-78°C; 5 h;
参考文献
Boschelli, Diane H.; Wu, Biqi; Sosa, Ana Carolina Barrios; Durutlic, Haris; Ye, Fei; Raifeld, Yuri; Golas, Jennifer M.; Boschelli, Frank
Journal of Medicinal Chemistry, 2004 , vol. 47, # 27 p. 6666 - 6668
反应条件
iodine; sodium thiosulfate; lithium diisopropyl amide in tetrahydrofuran; n-heptane; dichloromethane; chloroform; ethylbenzene; water
参考文献
Wyeth
Patent: US2004/242883 A1, 2004 ;
US 20040242883 A1
反应条件
N-bromosuccinmide in N,N-dimethyl-formamide
T=40 - 60°C; 75 h;
参考文献
Boschelli, Diane H.; Wu, Biqi; Sosa, Ana Carolina Barrios; Durutlic, Haris; Ye, Fei; Raifeld, Yuri; Golas, Jennifer M.; Boschelli, Frank
Journal of Medicinal Chemistry, 2004 , vol. 47, # 27 p. 6666 - 6668
反应条件
N-bromosuccinmide; acetic acid
T=65 - 90°C; 9 h; Title compound not separated from byproducts;
参考文献
Boschelli, Diane H.; Wu, Biqi; Sosa, Ana Carolina Barrios; Durutlic, Haris; Ye, Fei; Raifeld, Yuri; Golas, Jennifer M.; Boschelli, Frank
Journal of Medicinal Chemistry, 2004 , vol. 47, # 27 p. 6666 - 6668
