7-氯噻吩并[3,2-b]吡啶-6-甲酰胺合成路线 （共 7 条）
反应条件
in DMF (N,N-dimethyl-formamide) 0.5 h;
参考文献
WYETH
Patent: WO2004/48386 A2, 2004 ;
Location in patent: Page 75 ;
WO 2004/048386 A2
反应条件
in N,N-dimethyl-formamide
参考文献
Wyeth
Patent: US2004/242883 A1, 2004 ;
US 20040242883 A1
反应条件
2,4,6-trichloro-1,3,5-triazine in N,N-dimethyl-formamide 0.5 h;
参考文献
Boschelli, Diane H.; Wu, Biqi; Sosa, Ana Carolina Barrios; Durutlic, Haris; Ye, Fei; Raifeld, Yuri; Golas, Jennifer M.; Boschelli, Frank
Journal of Medicinal Chemistry, 2004 , vol. 47, # 27 p. 6666 - 6668
反应条件
1: thionyl chloride / 2 h / Heating
2: 10.9 g / aq. ammonia / acetone / 10 °C
View Scheme
参考文献
Boschelli, Diane H.; Wu, Biqi; Sosa, Ana Carolina Barrios; Durutlic, Haris; Ye, Fei; Raifeld, Yuri; Golas, Jennifer M.; Boschelli, Frank
Journal of Medicinal Chemistry, 2004 , vol. 47, # 27 p. 6666 - 6668
反应条件
1: 2.47 g / aq. NaOH / ethanol / 1 h / Heating
2: thionyl chloride / 2 h / Heating
3: 10.9 g / aq. ammonia / acetone / 10 °C
View Scheme
参考文献
Boschelli, Diane H.; Wu, Biqi; Sosa, Ana Carolina Barrios; Durutlic, Haris; Ye, Fei; Raifeld, Yuri; Golas, Jennifer M.; Boschelli, Frank
Journal of Medicinal Chemistry, 2004 , vol. 47, # 27 p. 6666 - 6668
反应条件
1.1: 9.0 g / cyanuric chloride / dimethylformamide / 0.5 h
2.1: LDA / heptane; tetrahydrofuran; ethylbenzene / 0.33 h / -78 °C
2.2: 750 mg / iodine / heptane; tetrahydrofuran; ethylbenzene / 5 h / -78 °C
View Scheme
参考文献
Boschelli, Diane H.; Wu, Biqi; Sosa, Ana Carolina Barrios; Durutlic, Haris; Ye, Fei; Raifeld, Yuri; Golas, Jennifer M.; Boschelli, Frank
Journal of Medicinal Chemistry, 2004 , vol. 47, # 27 p. 6666 - 6668
反应条件
1: 9.0 g / cyanuric chloride / dimethylformamide / 0.5 h
2: 35 mg / N-bromosuccinimide / dimethylformamide / 75 h / 40 - 60 °C
View Scheme
参考文献
Boschelli, Diane H.; Wu, Biqi; Sosa, Ana Carolina Barrios; Durutlic, Haris; Ye, Fei; Raifeld, Yuri; Golas, Jennifer M.; Boschelli, Frank
Journal of Medicinal Chemistry, 2004 , vol. 47, # 27 p. 6666 - 6668
