4-氯噻吩并[2,3-b]吡啶-5-羧酸合成路线 （共 5 条）
反应条件
sodium hydroxide in ethanol
1.5 h; Heating;
参考文献
Boschelli, Diane H.; Wu, Biqi; Sosa, Ana Carolina Barrios; Durutlic, Haris; Ye, Fei; Raifeld, Yuri; Golas, Jennifer M.; Boschelli, Frank
Journal of Medicinal Chemistry, 2004 , vol. 47, # 27 p. 6666 - 6668
反应条件
1.1: thionyl chloride / 2 h / Heating
2.1: 175 mg / aq. ammonia / acetone / 2 h / 0 °C
3.1: 84 mg / cyanuric chloride / dimethylformamide / 0.5 h / 20 °C
4.1: LDA / heptane; tetrahydrofuran; ethylbenzene / 0.58 h / -78 °C
4.2: 1.0 g / iodine / tetrahydrofuran; heptane; ethylbenzene / 4 h / -78 °C
View Scheme
参考文献
Boschelli, Diane H.; Wu, Biqi; Sosa, Ana Carolina Barrios; Durutlic, Haris; Ye, Fei; Raifeld, Yuri; Golas, Jennifer M.; Boschelli, Frank
Journal of Medicinal Chemistry, 2004 , vol. 47, # 27 p. 6666 - 6668
反应条件
1: thionyl chloride / 2 h / Heating
2: 175 mg / aq. ammonia / acetone / 2 h / 0 °C
View Scheme
参考文献
WYETH
Patent: WO2004/48386 A2, 2004 ;
Location in patent: Page 82 ;
WO 2004/048386 A2
反应条件
thionyl chloride in water; acetone
参考文献
Wyeth
Patent: US2004/242883 A1, 2004 ;
US 20040242883 A1
反应条件
1: thionyl chloride / 2 h / Heating
2: 175 mg / aq. ammonia / acetone / 2 h / 0 °C
3: 84 mg / cyanuric chloride / dimethylformamide / 0.5 h / 20 °C
View Scheme
参考文献
Boschelli, Diane H.; Wu, Biqi; Sosa, Ana Carolina Barrios; Durutlic, Haris; Ye, Fei; Raifeld, Yuri; Golas, Jennifer M.; Boschelli, Frank
Journal of Medicinal Chemistry, 2004 , vol. 47, # 27 p. 6666 - 6668
