9-(2-氯-6-氟苄基)-6-二甲基氨基嘌呤合成路线 （共 8 条）
反应条件
potassium carbonate in N,N-dimethyl acetamide
参考文献
Takeda Chemical Industries, Ltd.
Patent: US4189485 A1, 1980 ;
反应条件
sodium hydroxide; nitric acid in nitrogen; water; acetone
参考文献
Takeda Chemical Industries, Ltd.
Patent: US4423219 A1, 1983 ;
反应条件
sulfuric acid in acetone; toluene
参考文献
Takeda Chemical Industries, Ltd.
Patent: US4423219 A1, 1983 ;
反应条件
1: 67 percent / phosphoryl chloride, tripropyl amine / 0.67 h / Heating
2: 2.49 g / methanol / 3 h / 110 - 120 °C
View Scheme
参考文献
Imai; Seo
European Journal of Medicinal Chemistry, 1980 , vol. 15, # 3 p. 207 - 210
反应条件
1: 77 percent / sodium nitrite / acetic acid; H2O / 2 h / 60 - 70 °C
2: 67 percent / phosphoryl chloride, tripropyl amine / 0.67 h / Heating
3: 2.49 g / methanol / 3 h / 110 - 120 °C
View Scheme
参考文献
Imai; Seo
European Journal of Medicinal Chemistry, 1980 , vol. 15, # 3 p. 207 - 210
反应条件
in methanol
T=110 - 120°C; 3 h;
参考文献
Imai; Seo
European Journal of Medicinal Chemistry, 1980 , vol. 15, # 3 p. 207 - 210
反应条件
sodium hydride
1.) DMF, 1 h; 2.) 2 h; Yield given. Multistep reaction;
参考文献
Imai; Seo
European Journal of Medicinal Chemistry, 1980 , vol. 15, # 3 p. 207 - 210
反应条件
sodium hydride
1.) DMF, 1 h; 2.) 2 h; Yield given. Multistep reaction;
参考文献
Imai; Seo
European Journal of Medicinal Chemistry, 1980 , vol. 15, # 3 p. 207 - 210
