2-(4-硝基苯基)-4-喹啉羧酸合成路线 （共 11 条）
参考文献
Chem. Fabr. Schering
Patent: DE279195 ;
Fortschr. Teerfarbenfabr. Verw. Industriezweige, vol. 12, p. 713
反应条件
sulfuric acid; nitric acid
T=20 - 50°C; 4 h;
参考文献
Sommerauer, Michael; Rager, Christine; Hanack, Michael
Journal of the American Chemical Society, 1996 , vol. 118, # 42 p. 10085 - 10093
反应条件
sulfuric acid in acetic acid
Heating;
参考文献
Belen'kaya, R. S.; Boreko, E. I.; Zemtsova, M. N.; Kalinina, M. I.; Timofeeva, M. M.; et al.
Pharmaceutical Chemistry Journal, 1981 , vol. 15, # 3 p. 171 - 176
Khimiko-Farmatsevticheskii Zhurnal, 1981 , vol. 15, # 3 p. 29 - 35
反应条件
[Yb(PFO)3] in water
Doebner reaction; 3 h; Reflux;
参考文献
Wang, Li-Min; Hu, Liang; Chen, Hong-Juan; Sui, Yuan-Yuan; Shen, Wei
Journal of Fluorine Chemistry, 2009 , vol. 130, # 4 p. 406 - 409
反应条件
1: 78 percent / conc. aq. NH3 / ethanol / 24 h / Ambient temperature
2: 76 percent / aq. H2SO4 / acetic acid / Heating
View Scheme
参考文献
Belen'kaya, R. S.; Boreko, E. I.; Zemtsova, M. N.; Kalinina, M. I.; Timofeeva, M. M.; et al.
Pharmaceutical Chemistry Journal, 1981 , vol. 15, # 3 p. 171 - 176
Khimiko-Farmatsevticheskii Zhurnal, 1981 , vol. 15, # 3 p. 29 - 35
反应条件
1: 78 percent / conc. aq. NH3 / ethanol / 24 h / Ambient temperature
2: 76 percent / aq. H2SO4 / acetic acid / Heating
View Scheme
参考文献
Belen'kaya, R. S.; Boreko, E. I.; Zemtsova, M. N.; Kalinina, M. I.; Timofeeva, M. M.; et al.
Pharmaceutical Chemistry Journal, 1981 , vol. 15, # 3 p. 171 - 176
Khimiko-Farmatsevticheskii Zhurnal, 1981 , vol. 15, # 3 p. 29 - 35
反应条件
1: potassium carbonate / N,N-dimethyl-formamide / 20 °C / Inert atmosphere
2: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II) dichloromethane adduct / N,N-dimethyl-formamide; 1,4-dioxane / 85 °C / Inert atmosphere
3: sodium hydroxide; water
View Scheme
参考文献
Pharma Ip General Incorporated Association; Pharma Design Inc.; Shizuoka Prefecture; Kumamoto Health Science University; Kabushiki Kaisha Yakult Honsha
Patent: EP2325181 A1, 2011 ;
反应条件
1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II) dichloromethane adduct / N,N-dimethyl-formamide; 1,4-dioxane / 85 °C / Inert atmosphere
2: sodium hydroxide; water
View Scheme
参考文献
Pharma Ip General Incorporated Association; Pharma Design Inc.; Shizuoka Prefecture; Kumamoto Health Science University; Kabushiki Kaisha Yakult Honsha
Patent: EP2325181 A1, 2011 ;
反应条件
hydrogenchloride in ethanol
Heating;
参考文献
Belen'kaya, R. S.; Boreko, E. I.; Zemtsova, M. N.; Kalinina, M. I.; Timofeeva, M. M.; et al.
Pharmaceutical Chemistry Journal, 1981 , vol. 15, # 3 p. 171 - 176
Khimiko-Farmatsevticheskii Zhurnal, 1981 , vol. 15, # 3 p. 29 - 35
反应条件
sulfuric acid in acetic acid
Yield given;
参考文献
Belen'kaya, R. S.; Boreko, E. I.; Zemtsova, M. N.; Kalinina, M. I.; Timofeeva, M. M.; et al.
Pharmaceutical Chemistry Journal, 1981 , vol. 15, # 3 p. 171 - 176
Khimiko-Farmatsevticheskii Zhurnal, 1981 , vol. 15, # 3 p. 29 - 35
