4-氟-N-甲基苯甲酰胺合成路线 （共 11 条）
反应条件
1: With triethylamine in tetrahydrofuran; 1,2-dichloro-ethane T=20°C; 0.166667 h; 2: With benzotriazol-1-ol; dicyclohexyl-carbodiimide in tetrahydrofuran; 1,2-dichloro-ethane T=70°C; 3 h;
参考文献
EVOTEC NEUROSCIENCES GMBH
Patent: WO2009/135842 A1, 2009 ;
Location in patent: Page/Page column 67-68 ;
WO 2009/135842 A1
反应条件
copper(l) chloride in chlorobenzene T=130°C; 12 h; Schlenk techniqueInert atmosphere;
参考文献
Xia, Qinqin; Liu, Xiaolong; Zhang, Yuejiao; Chen, Chao; Chen, Wanzhi
Organic Letters, 2013 , vol. 15, # 13 p. 3326 - 3329
反应条件
4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride in N,N-dimethyl-formamide T=23°C; 3 h;
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 23, # 16 p. 4501 - 4505
反应条件
N,N,N',N'-tetramethyl-7,8-dihydro-6H-dipyrido[1,2-a;2',1'-c][1,4] diazepine-2,12-diamine in N,N-dimethyl-formamide T=20°C;
参考文献
Cutulic, Sylvain P. Y.; Murphy, John A.; Farwaha, Hardeep; Zhou, Sheng-Ze; Chrystal, Ewan
Synlett, 2008 , # 14 p. 2132 - 2136
反应条件
potassium carbonate in diethyl ether T=20°C;
参考文献
Ackermann, Lutz; Lygin, Alexander V.; Hofmann, Nora
Angewandte Chemie - International Edition, 2011 , vol. 50, # 28 p. 6379 - 6382
反应条件
1,4-diaza-bicyclo[2.2.2]octane in chloroform-d1
参考文献
Spratt, M. P.; Dorn, H. C.
Analytical Chemistry, 1984 , vol. 56, # 12 p. 2038 - 2043
反应条件
N-bromosuccinmide in chloroform T=20°C; 18 h; Product distribution;
参考文献
Kuang, Liping; Zhou, Jing; Chen, Sheng; Ding, Ke
Synthesis, 2007 , # 20 p. 3129 - 3134
反应条件
in chloroform-d1 6 h; Ambient temperature;
参考文献
Journal of Organic Chemistry, , vol. 57, # 16 p. 4487 - 4490
参考文献
Salfetnikova; Vasil'ev; Rudenko
Russian Journal of Organic Chemistry, 1998 , vol. 34, # 6 p. 838 - 844
反应条件
1: thionyl chloride / dichloromethane; N,N-dimethyl-formamide / 3 h / 60 °C / |Inert atmosphere; |Schlenk technique 2: triethylamine / diethyl ether; methanol / 1 h / 20 °C / |Inert atmosphere; |Schlenk technique View Scheme
参考文献
Journal of the American Chemical Society, , vol. 135, # 12 p. 4628 - 4631
