7-氯-2-甲基-4-羟基喹唑啉合成路线 （共 9 条）
反应条件
copper(l) iodide; potassium carbonate in N,N-dimethyl-formamide T=80°C; 6 h; Inert atmosphere;
参考文献
Zhou, Jing; Fu, Liangbing; Lv, Man; Liu, Jinsong; Pei, Duanqing; Ding, Ke
Synthesis, 2008 , # 24 art. no. F18308SS, p. 3974 - 3980
反应条件
1: in N,N-dimethyl-formamide T=20°C; 0.166667 h; Inert atmosphere; 2: With iron (III) acetylacetonate; caesium carbonate; N-methyl-2-(methylamino)ethylamine in N,N-dimethyl-formamide Microwave irradiationInert atmosphere;
参考文献
Zhang, Xiaodong; Ye, Deju; Sun, Haifeng; Guo, Diliang; Wang, Jiang; Huang, He; Zhang, Xu; Jiang, Hualiang; Liu, Hong
Green Chemistry, 2009 , vol. 11, # 11 p. 1881 - 1888
反应条件
formamide T=140 - 150°C; 3 h;
参考文献
El-Meligie; El-Ansary; Said; Hussein
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2001 , vol. 40, # 1 p. 62 - 69
反应条件
1: pyridine / dichloromethane / 2 h / 20 °C / Inert atmosphere 2: water; sodium hydroxide / 1 h / Reflux; Inert atmosphere View Scheme
参考文献
European Journal of Organic Chemistry, , # 31 p. 5996 - 6004
反应条件
water; sodium hydroxide 1 h; RefluxInert atmosphere;
参考文献
Fleming, William J.; Mueller-Bunz, Helge; Guiry, Patrick J.
European Journal of Organic Chemistry, 2010 , # 31 p. 5996 - 6004
反应条件
1: 88 percent / 25percent aq. NH3 / 6 h / 126 - 129 °C / 3800 - 9120 Torr 2: 3 h / 110 - 120 °C 3: 78.4 percent / 25percent aq. NH3 / 1.) 0-5 deg C, 2) 48-50 deg C, 10 h View Scheme
参考文献
Pharmaceutical Chemistry Journal, , vol. 21, # 1 p. 34 - 45
Khimiko-Farmatsevticheskii Zhurnal, , vol. 21, # 1 p. 38 - 49
反应条件
1: 68 percent / 25percent aq. NH3, cupric acetate / 10 h / 126 - 129 °C 2: 3 h / 110 - 120 °C 3: 78.4 percent / 25percent aq. NH3 / 1.) 0-5 deg C, 2) 48-50 deg C, 10 h View Scheme
参考文献
Pharmaceutical Chemistry Journal, , vol. 21, # 1 p. 34 - 45
Khimiko-Farmatsevticheskii Zhurnal, , vol. 21, # 1 p. 38 - 49
反应条件
1: 3 h / 110 - 120 °C 2: 78.4 percent / 25percent aq. NH3 / 1.) 0-5 deg C, 2) 48-50 deg C, 10 h View Scheme
参考文献
Pharmaceutical Chemistry Journal, , vol. 21, # 1 p. 34 - 45
Khimiko-Farmatsevticheskii Zhurnal, , vol. 21, # 1 p. 38 - 49
反应条件
N,N-diethylaniline; trichlorophosphate in benzene 16 h; RefluxInert atmosphere;
参考文献
Fleming, William J.; Mueller-Bunz, Helge; Guiry, Patrick J.
European Journal of Organic Chemistry, 2010 , # 31 p. 5996 - 6004
