2-溴-5-(1,1-二甲基庚基)苯酚合成路线 （共 12 条）
反应条件
bromine in tetrachloromethane
T=30°C; 0.25 h;
参考文献
Melvin, Lawrence S.; Johnson, M. Ross; Harbert, Charles A.; Milne, George M.; Weissman, Albert
Journal of Medicinal Chemistry, 1984 , vol. 27, # 1 p. 67 - 71
反应条件
1: NaH / dimethylsulfoxide
2: H2 / Pd/C
3: Br2 / CCl4
View Scheme
参考文献
Worm, Karin; Zhou, Q. Jean; Stabley, Gabriel J.; DeHaven, Robert N.; Dolle, Roland E.
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 13 p. 3652 - 3656
反应条件
1: DIBAL-H; aq. H2SO4
2: NaH / dimethylsulfoxide
3: H2 / Pd/C
4: Br2 / CCl4
View Scheme
参考文献
Worm, Karin; Zhou, Q. Jean; Stabley, Gabriel J.; DeHaven, Robert N.; Dolle, Roland E.
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 13 p. 3652 - 3656
反应条件
1: NaH / dimethylsulfoxide
2: H2 / Pd/C
3: Br2 / CCl4
View Scheme
参考文献
Worm, Karin; Zhou, Q. Jean; Stabley, Gabriel J.; DeHaven, Robert N.; Dolle, Roland E.
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 13 p. 3652 - 3656
反应条件
1: 78 percent / H2 / 10percent Pd/C / ethanol / 13 h / 2585.7 Torr
2: 100 percent / Br2 / CCl4 / 0.25 h / 30 °C
View Scheme
参考文献
Melvin, Lawrence S.; Johnson, M. Ross; Harbert, Charles A.; Milne, George M.; Weissman, Albert
Journal of Medicinal Chemistry, 1984 , vol. 27, # 1 p. 67 - 71
反应条件
1: H2 / Pd/C
2: Br2 / CCl4
View Scheme
参考文献
Worm, Karin; Zhou, Q. Jean; Stabley, Gabriel J.; DeHaven, Robert N.; Dolle, Roland E.
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 13 p. 3652 - 3656
反应条件
1: 1.) KH / 1.) DMF, -18 deg C, 15 min, 2.) 25 deg C, 30 min
2: Mg / tetrahydrofuran / 20 h / Heating
3: CuI / tetrahydrofuran / 0.5 h / -3 °C
View Scheme
参考文献
Melvin, Lawrence S.; Johnson, M. Ross; Harbert, Charles A.; Milne, George M.; Weissman, Albert
Journal of Medicinal Chemistry, 1984 , vol. 27, # 1 p. 67 - 71
反应条件
1: 1.) KH / 1.) DMF, -18 deg C, 15 min, 2.) 25 deg C, 30 min
2: Mg / tetrahydrofuran / 20 h / Heating
3: CuI / tetrahydrofuran / 0.5 h / -3 °C
4: 35 percent / H2, NaHCO3 / 10percent Pd/C / ethanol / 2 h / 760 Torr
View Scheme
参考文献
Melvin, Lawrence S.; Johnson, M. Ross; Harbert, Charles A.; Milne, George M.; Weissman, Albert
Journal of Medicinal Chemistry, 1984 , vol. 27, # 1 p. 67 - 71
反应条件
potassium hydride
1.) DMF, -18 deg C, 15 min, 2.) 25 deg C, 30 min; Multistep reaction;
参考文献
Pfizer Inc.
Patent: US4306097 A1, 1981 ;
反应条件
1: 1.) KH / 1.) DMF, -18 deg C, 15 min, 2.) 25 deg C, 30 min
2: Mg / tetrahydrofuran / 20 h / Heating
3: CuI / tetrahydrofuran / 0.5 h / -3 °C
View Scheme
参考文献
Melvin, Lawrence S.; Johnson, M. Ross; Harbert, Charles A.; Milne, George M.; Weissman, Albert
Journal of Medicinal Chemistry, 1984 , vol. 27, # 1 p. 67 - 71
