(1R,3r,4s)-4-((叔丁基二甲基甲硅烷基)氧基)-3-(((叔丁基二甲基甲硅烷基)氧基)甲基)-2-亚甲基环戊醇合成路线 （共 10 条）
反应条件
1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran 2: hydrogenchloride / tetrahydrofuran; methanol; water / 55 °C View Scheme
参考文献
Zhejiang Ausun Pharmaceutical Co., Ltd.; ZHENG, Zhiguo
Patent: EP2594569 A1, 2013 ;
Title/Abstract Full Text Show Details
AUSUN PHARMATECH. CO., LTD.; Zheng, Zhiguo
Patent: US2013/217879 A1, 2013 ;
反应条件
1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran 2: hydrogenchloride / tetrahydrofuran; methanol; water / 55 °C View Scheme
参考文献
Zhejiang Ausun Pharmaceutical Co., Ltd.; ZHENG, Zhiguo
Patent: EP2594569 A1, 2013 ;
Title/Abstract Full Text Show Details
AUSUN PHARMATECH. CO., LTD.; Zheng, Zhiguo
Patent: US2013/217879 A1, 2013 ;
反应条件
potassium carbonate in methanol
T=20°C; 1 h;
参考文献
AUSUN PHARMATECH. CO., LTD.; Zheng, Zhiguo
Patent: US2013/217879 A1, 2013 ;
Location in patent: Paragraph 0210-0212 ;
反应条件
1: With 2,2,6,6-tetramethyl-piperidine; n-butyllithium; diethylaluminium chloride in hexane; toluene
T=0°C; 20.25 h; Inert atmosphere;
2: With methanol in hexane; toluene
regioselective reaction;
参考文献
Liu, Xiaoyu; Jiao, Xiaozhen; Wu, Qian; Tian, Chengsen; Li, Renze; Xie, Ping
Tetrahedron Letters, 2012 , vol. 53, # 29 p. 3805 - 3807
反应条件
lithium triethylborohydride in tetrahydrofuran
T=-78°C; diastereoselective reaction;
参考文献
Zhou, Bing; Li, Yuanchao
Tetrahedron Letters, 2012 , vol. 53, # 5 p. 502 - 504
反应条件
1: pyridine; copper diacetate; lead(IV) tetraacetate / toluene / 1 h / |Reflux
2: potassium carbonate / methanol / 1 h / 20 °C
View Scheme
参考文献
Zhejiang Ausun Pharmaceutical Co., Ltd.; ZHENG, Zhiguo
Patent: EP2594569 A1, 2013 ;
反应条件
1: 1H-imidazole / N,N-dimethyl-formamide / 2 h / 20 °C
2: 2,2,6,6-tetramethyl-piperidine; n-butyllithium; diethylaluminium chloride / hexane; toluene / 20.25 h / 0 °C / Inert atmosphere
View Scheme
参考文献
Liu, Xiaoyu; Jiao, Xiaozhen; Wu, Qian; Tian, Chengsen; Li, Renze; Xie, Ping
Tetrahedron Letters, 2012 , vol. 53, # 29 p. 3805 - 3807
反应条件
1: 1H-imidazole / N,N-dimethyl-formamide / 10 h / 0 - 20 °C
2: Grubb's 2nd generation catalyst / dichloromethane / 3 h / Reflux
3: tert.-butylhydroperoxide; bis(acetylacetonate)oxovanadium / 1,2-dichloro-ethane / 2 h / 0 - 20 °C
4: 1H-imidazole / N,N-dimethyl-formamide / 2 h / 20 °C
5: 2,2,6,6-tetramethyl-piperidine; n-butyllithium; diethylaluminium chloride / hexane; toluene / 20.25 h / 0 °C / Inert atmosphere
View Scheme
参考文献
Liu, Xiaoyu; Jiao, Xiaozhen; Wu, Qian; Tian, Chengsen; Li, Renze; Xie, Ping
Tetrahedron Letters, 2012 , vol. 53, # 29 p. 3805 - 3807
反应条件
1: Grubb's 2nd generation catalyst / dichloromethane / 3 h / Reflux
2: tert.-butylhydroperoxide; bis(acetylacetonate)oxovanadium / 1,2-dichloro-ethane / 2 h / 0 - 20 °C
3: 1H-imidazole / N,N-dimethyl-formamide / 2 h / 20 °C
4: 2,2,6,6-tetramethyl-piperidine; n-butyllithium; diethylaluminium chloride / hexane; toluene / 20.25 h / 0 °C / Inert atmosphere
View Scheme
参考文献
Liu, Xiaoyu; Jiao, Xiaozhen; Wu, Qian; Tian, Chengsen; Li, Renze; Xie, Ping
Tetrahedron Letters, 2012 , vol. 53, # 29 p. 3805 - 3807
反应条件
1: tert.-butylhydroperoxide; bis(acetylacetonate)oxovanadium / 1,2-dichloro-ethane / 2 h / 0 - 20 °C
2: 1H-imidazole / N,N-dimethyl-formamide / 2 h / 20 °C
3: 2,2,6,6-tetramethyl-piperidine; n-butyllithium; diethylaluminium chloride / hexane; toluene / 20.25 h / 0 °C / Inert atmosphere
View Scheme
参考文献
Liu, Xiaoyu; Jiao, Xiaozhen; Wu, Qian; Tian, Chengsen; Li, Renze; Xie, Ping
Tetrahedron Letters, 2012 , vol. 53, # 29 p. 3805 - 3807
