3-氟-2-羟基-苯甲酸甲酯合成路线 （共 6 条）
反应条件
sulfuric acid 18 h; Heating / reflux;
参考文献
Kudos Pharmaceuticals Ltd.
Patent: US2006/135770 A1, 2006 ;
Location in patent: Page/Page column 27-28 ;
US 20060135770 A1
反应条件
boron trifluoride-methanol; sodium hydrogencarbonate in methanol
反应条件
AcOF in dichloromethane; monofluoro-trichloromethane T=-75°C;
参考文献
Journal of Organic Chemistry, , vol. 49, p. 806 - 813
反应条件
lithium hydroxide T=20°C; 6 h;
参考文献
Dobler, Markus R.
Organic and Biomolecular Chemistry, 2004 , vol. 2, # 7 p. 963 - 964
反应条件
1.1: BCl3; AlCl3 / 1,2-dichloro-ethane / 4 h / 20 °C 1.2: 63 percent / aq. HCl / 1,2-dichloro-ethane / 0.17 h / 20 °C 2.1: 100 percent / aq. LiOH / 6 h / 20 °C View Scheme
参考文献
Organic and Biomolecular Chemistry, , vol. 2, # 7 p. 963 - 964
反应条件
ammonia in methanol
T=110°C; 16 h;
参考文献
SMITHKLINE BEECHAM CORPORATION
Patent: WO2007/62370 A2, 2007 ;
Location in patent: Page/Page column 46 ;
