3-氟-4-(甲基氧基)苯甲酰胺合成路线 （共 3 条）
反应条件
1: With sodium tetrahydroborate; boron trifluoride diethyl etherate in tetrahydrofuran 15 h; Heating / reflux; 2: With water; citric acid in tetrahydrofuran; ethyl acetate 3: With sodium hydrogencarbonate in water pH=8;
参考文献
EXELIXIS, INC.
Patent: WO2009/55077 A1, 2009 ;
Location in patent: Page/Page column 372 ;
反应条件
ammonium hydroxide in dichloromethane
T=0 - 20°C;
参考文献
Lori, Franco; Chafouleas, James; De Forni, Davide; Solinas, Antonio; Varga, Zoltán; Greff, Zoltán; Örfi, László; Kéri, György
Patent: US2014/57911 A1, 2014 ;
Location in patent: Paragraph 0509; 05010 ;
反应条件
1: With triethylamine; isobutyl chloroformate in tetrahydrofuran
T=0°C; 1 h;
2: With ammonia in tetrahydrofuran
T=20°C; 15 h;
参考文献
EXELIXIS, INC.
Patent: WO2009/55077 A1, 2009 ;
Location in patent: Page/Page column 371 ;
