1: sulfuric acid / tetrahydrofuran; water / 10 h / Reflux 2: sodium tungstate; dihydrogen peroxide / tetrahydrofuran; water / 0.5 h / 20 °C 3: tert.-butylhydroperoxide; C3H7O(1-)*C34H32N2O4(2-)*V(3+) / dichloromethane; water / 72 h / 0 °C 4: N,N-dimethyl-formamide / 10 h / 20 °C 5: sodium hydride / N,N-dimethyl-formamide / 1 h / 20 °C 6: triethylamine / dichloromethane / 2 h / 0 - 20 °C 7: 1,8-diazabicyclo[5.4.0]undec-7-ene / toluene / 8 h / 90 °C 8: potassium hydroxide / methanol; water / 1 h / Reflux; Inert atmosphere 9: palladium 10 on activated carbon; formic acid / methanol / 10 h / 20 °C / Inert atmosphere 10: hydrogenchloride / water; isopropyl alcohol / 16 h / 50 - 70 °C 11: nonafluoro-n-butanesulfonyl fluoride; triethylamine tris(hydrogen fluoride); triethylamine / tetrahydrofuran / 12 h / 20 °C 12: sodium acetate / water; isopropyl alcohol / 3 h / pH 5 / Reflux View Scheme

1.1: 95 percent / oxone / tetrahydrofuran; methanol; H2O / 0 - 25 °C 2.1: 43 percent / Ti(O-iPr)4; (+)-diisopropyl tartrate; tert-butyl hydroperoxide / molecular sieves 4 Angstroem / CH2Cl2 / 24 h / -20 °C 3.1: CH2Cl2 / 2 h / 0 - 25 °C 3.2: 86 percent / potassium carbonate / methanol; H2O / 18 h / 0 - 25 °C 4.1: 65 percent / sodium hydroxide; tert-butyl hypochlorite; potassium osmate / ethyldiisopropylamine / propan-1-ol; H2O / 3 h / 25 °C 5.1: NaOH / methanol; H2O / 25 °C 5.2: 77 percent / 3 h / 90 °C View Scheme

1: sulfuric acid / tetrahydrofuran; water / 10 h / Reflux 2: sodium tungstate; dihydrogen peroxide / tetrahydrofuran; water / 0.5 h / 20 °C View Scheme