hydrogen; bis(norbornadiene)rhodium(I) tetrafluoroborate; (R,S)-(di-t-butylphosphino)ferrocenyl-ethyldi-o-tolyl-phosphine in 1,2-dichloro-ethane T=80°C; P=25858.1 Torr; 18 h;

2,4,6-trichloro-1,3,5-triazine in isopropanol acetate; N,N-dimethyl-formamide T=25°C; 1.5 h; Inert atmosphere; optical yield given as percent ee;

triethylamine in acetonitrile T=0 - 10°C; 0.5 h;

bis(1,5-cyclooctadiene)-rhodium(I) tetrafluoroborate; C36H48FeP2; hydrogen in isopropanol acetate; N,N-dimethyl-formamide T=90°C; P=25858.1 Torr; optical yield given as percent eeregioselective reaction;

4-methyl-morpholine; 2,4,6-trichloro-1,3,5-triazine in acetonitrile T=50°C; 4 h; Inert atmosphereLarge scale;

1: LiBH(sec-Bu)3 / tetrahydrofuran / 0.5 h / 0 °C 2: Et3N / ethyl acetate / 0.5 h / 0 °C 3: NaN3 / dimethylformamide / 1 h / 120 °C 4: H2 / PtO2 / ethyl acetate / 24 h 5: tris(dibenzylideneacetone)dipalladium chloroform complex; 1,1'-bis(diphenylphosphino)ferrocene / dimethylformamide; H2O / 24 h / 120 °C 6: HCl / ethyl acetate / 0.5 h / 20 °C 7: N-methylmorpholine; PyBOP / CH2Cl2 / 20 °C View Scheme

1: sodium hexamethyldisilazide / tetrahydrofuran / -78 - 20 °C 2: Me2AlCl / 20 °C 3: tetrahydrofuran / 2 h / 0 °C 4: LiBH(sec-Bu)3 / tetrahydrofuran / 0.5 h / 0 °C 5: Et3N / ethyl acetate / 0.5 h / 0 °C 6: NaN3 / dimethylformamide / 1 h / 120 °C 7: H2 / PtO2 / ethyl acetate / 24 h 8: tris(dibenzylideneacetone)dipalladium chloroform complex; 1,1'-bis(diphenylphosphino)ferrocene / dimethylformamide; H2O / 24 h / 120 °C 9: HCl / ethyl acetate / 0.5 h / 20 °C 10: N-methylmorpholine; PyBOP / CH2Cl2 / 20 °C View Scheme

1: sodium hexamethyldisilazide / tetrahydrofuran / -78 - 20 °C 2: Me2AlCl / 20 °C 3: tetrahydrofuran / 2 h / 0 °C 4: LiBH(sec-Bu)3 / tetrahydrofuran / 0.5 h / 0 °C 5: Et3N / ethyl acetate / 0.5 h / 0 °C 6: NaN3 / dimethylformamide / 1 h / 120 °C 7: H2 / PtO2 / ethyl acetate / 24 h 8: tris(dibenzylideneacetone)dipalladium chloroform complex; 1,1'-bis(diphenylphosphino)ferrocene / dimethylformamide; H2O / 24 h / 120 °C 9: HCl / ethyl acetate / 0.5 h / 20 °C 10: N-methylmorpholine; PyBOP / CH2Cl2 / 20 °C View Scheme

4-methyl-morpholine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate in dichloromethane T=20°C;

1: NaOH / acetonitrile; H2O / 50 °C 2: N-methylmorpholine; PyBOP / CH2Cl2 / 20 °C View Scheme