4-(2-氯苯酰胺)苯甲酸合成路线 （共 4 条）
反应条件
1: With triethylamine in acetonitrile
T=20°C; 4 h; Inert atmosphere;
2: With sodium hydroxide in diethyl ether; water
3: With hydrogenchloride in water
pH=2;
参考文献
AMGEN INC.
Patent: WO2009/151495 A2, 2009 ;
Location in patent: Page/Page column 54-55 ;
WO 2009/151495 A2
反应条件
methanol; sodium hydroxide in tetrahydrofuran
T=20°C; 2 h;
参考文献
Zheng, Can-Hui; Yang, Hui; Zhang, Meng; Lu, Shi-Hai; Shi, Duo; Wang, Juan; Chen, Xiu-Hua; Ren, Xiao-Hui; Liu, Jia; Lv, Jia-Guo; Zhu, Ju; Zhou, You-Jun
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 1 p. 39 - 44
反应条件
1: 4-(N,N-dimethlyamino)pyridine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 3 h / 20 °C / Inert atmosphere
2: methanol; sodium hydroxide / tetrahydrofuran / 2 h / 20 °C
View Scheme
参考文献
Zheng, Can-Hui; Yang, Hui; Zhang, Meng; Lu, Shi-Hai; Shi, Duo; Wang, Juan; Chen, Xiu-Hua; Ren, Xiao-Hui; Liu, Jia; Lv, Jia-Guo; Zhu, Ju; Zhou, You-Jun
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 1 p. 39 - 44
反应条件
1: 4-(N,N-dimethlyamino)pyridine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 3 h / 20 °C / Inert atmosphere
2: methanol; sodium hydroxide / tetrahydrofuran / 2 h / 20 °C
View Scheme
参考文献
Zheng, Can-Hui; Yang, Hui; Zhang, Meng; Lu, Shi-Hai; Shi, Duo; Wang, Juan; Chen, Xiu-Hua; Ren, Xiao-Hui; Liu, Jia; Lv, Jia-Guo; Zhu, Ju; Zhou, You-Jun
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 1 p. 39 - 44
