4-(4-羟基苯基)丁酸合成路线 （共 20 条）
反应条件
boron tribromide in dichloromethane
参考文献
Chu, Lin; Hutchins, Jennifer E.; Weber, Ann E.; Lo, Jane-Ling; Yang, Yi-Tien; Cheng, Kang; Smith, Roy G.; Fisher, Michael H.; Wyvratt, Matthew J.; Goulet, Mark T.
Bioorganic and Medicinal Chemistry Letters, 2001 , vol. 11, # 4 p. 509 - 513
反应条件
1: With potassium hydroxide; hydrazine hydrate in 1,2-bis-(2-hydroxyethoxy)-ethane 1.5 h; Heating; 2: in 1,2-bis-(2-hydroxyethoxy)-ethane T=220°C; 4 h;
参考文献
Panda, Atulya Kumar
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2005 , vol. 44, # 2 p. 372 - 375
反应条件
hydrogenchloride; amalgamated zinc
参考文献
Journal of the American Chemical Society, , vol. 81, p. 871,872
反应条件
hydrogen bromide in acetic acid Heating;
参考文献
Journal of Medicinal Chemistry, , vol. 27, # 3 p. 325 - 341
反应条件
1.1: AlCl3 2.1: hydrazine hydrate; potassium hydroxide / triethylene glycol / 1.5 h / Heating 2.2: 87 percent / triethylene glycol / 4 h / 220 °C View Scheme
参考文献
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, , vol. 44, # 2 p. 372 - 375
反应条件
potassium carbonate in acetone 10 h; Heating;
参考文献
Panda, Atulya Kumar
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2005 , vol. 44, # 2 p. 372 - 375
反应条件
Yield given. Multistep reaction;
参考文献
Goromaru; Katashima; Matsuura; Yoshimura
Chemical and Pharmaceutical Bulletin, 1985 , vol. 33, # 9 p. 3922 - 3928
反应条件
1.1: NaH / dimethylformamide 1.2: aq. NaOH / methanol 2.1: N,O-dimethylhydroxylamine hydrochloride; HOBT; EDAC 2.2: 80 percent / DIBAL / tetrahydrofuran / -78 °C 3.1: CH2Cl2 4.1: H2 / Pd(OH)2 / methanol; ethyl acetate 5.1: 100 percent / aq. NaOH / methanol View Scheme
参考文献
Chu, Lin; Hutchins, Jennifer E.; Weber, Ann E.; Lo, Jane-Ling; Yang, Yi-Tien; Cheng, Kang; Smith, Roy G.; Fisher, Michael H.; Wyvratt, Matthew J.; Goulet, Mark T.
Bioorganic and Medicinal Chemistry Letters, 2001 , vol. 11, # 4 p. 509 - 513
反应条件
2: thionyl chloride / CHCl3 / 3 h / Heating 3: 0.9 g / KI, Na2CO3 / various solvent(s) / 48 h / Heating 4: 0.4 g / H2 / 5percent Pd-C / ethanol View Scheme
参考文献
Goromaru; Katashima; Matsuura; Yoshimura
Chemical and Pharmaceutical Bulletin, 1985 , vol. 33, # 9 p. 3922 - 3928
反应条件
sodium hydrogencarbonate in N,N-dimethyl-formamide
T=20°C; 5 h;
参考文献
American Cyanamid Company
Patent: US6340691 B1, 2002 ;
Location in patent: Page column 39 ;
US 6340691 B1
