5-(3,4-二甲氧基苯基)-2-苯基-1,3-恶唑合成路线 （共 12 条）
反应条件
copper(l) iodide; palladium diacetate; potassium carbonate in N,N-dimethyl-formamide
T=150°C; Microwave irradiation;
参考文献
Mahuteau-Betzer, Florence; Piguel, Sandrine
Tetrahedron Letters, 2013 , vol. 54, # 24 p. 3188 - 3193
反应条件
triphenylphosphine; silver carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride in dichloromethane; water
T=60°C; 24 h;
参考文献
Ohnmacht, Stephan A.; Mamone, Patrizia; Culshaw, Andrew J.; Greaney, Michael F.
Chemical Communications, 2008 , # 10 p. 1241 - 1243
反应条件
1: With lithium hydroxide in water; N,N-dimethyl-formamide
T=45°C; 12 h;
2: With hydrogenchloride in water
pH=5;
3: With copper(II) oxide in N,N-dimethyl-formamide
T=160°C; 70 h;
参考文献
Verrier, Cecile; Martin, Thibaut; Hoarau, Christophe; Marsais, Francis
Journal of Organic Chemistry, 2008 , vol. 73, # 18 p. 7383 - 7386
反应条件
1: 2,5-bis(methylthio)oxazole; PhZnCl With bis-triphenylphosphine-palladium(II) chloride in tetrahydrofuran
T=23°C; 1.5 h; Inert atmosphere;
2: 3,4-dimethoxyphenyl zinc chloride With NiCl2((PPh3)P)2 in tetrahydrofuran
T=65°C; 6 h; Inert atmosphere;
参考文献
Lee, Kyoungsoo; Counceller, Carla M.; Stambuli, James P.
Organic Letters, 2009 , vol. 11, # 6 p. 1457 - 1559
反应条件
copper(l) iodide; sodium carbonate; triphenylphosphine in N,N-dimethyl-formamide
T=160°C; 2 h; Inert atmosphere;
参考文献
Yoshizumi, Tomoki; Satoh, Tetsuya; Hirano, Koji; Matsuo, Daisuke; Orita, Akihiro; Otera, Junzo; Miura, Masahiro
Tetrahedron Letters, 2009 , vol. 50, # 26 p. 3273 - 3276
反应条件
1-methyl-1H-imidazole; copper dichloride in 1,4-dioxane
T=140°C; 20 h; Sealed tube;
参考文献
Wendlandt, Alison E.; Stahl, Shannon S.
Organic and Biomolecular Chemistry, 2012 , vol. 10, # 19 p. 3866 - 3870
反应条件
in water; N,N-dimethyl-formamide
T=150°C; 60 h;
参考文献
Hodgetts, Kevin J.; Kershaw, Mark T.
Organic Letters, 2002 , vol. 4, # 17 p. 2905 - 2907
反应条件
1: 86 percent / N-bromosuccinimide / CHCl3 / 48 h / Heating
2: 91 percent / K2CO3 / Pd(PPh3)4 / H2O; toluene / 90 °C
3: 95 percent / NaOH / ethanol / 20 °C
4: 74 percent / dimethylformamide; H2O / 60 h / 150 °C
View Scheme
参考文献
Hodgetts, Kevin J.; Kershaw, Mark T.
Organic Letters, 2002 , vol. 4, # 17 p. 2905 - 2907
反应条件
1: palladium diacetate; tetra-n-butylammonium acetate / N,N-dimethyl acetamide / 24 h / 70 °C / |Inert atmosphere
2: copper(l) iodide / 110 °C / |Inert atmosphere
View Scheme
参考文献
Bellina, Fabio; Lessi, Marco; Manzini, Chiara
European Journal of Organic Chemistry, 2013 , # 25 p. 5621 - 5630
反应条件
1: potassium carbonate / methanol / |Reflux
2: potassium carbonate; palladium diacetate; copper(l) iodide / N,N-dimethyl-formamide / 150 °C / |Microwave irradiation
View Scheme
参考文献
Mahuteau-Betzer, Florence; Piguel, Sandrine
Tetrahedron Letters, 2013 , vol. 54, # 24 p. 3188 - 3193
