1: 74 percent / NaH / dimethylformamide / 110 °C 2: TiCl4 / toluene / 0.5 h / 110 °C 3: 98 percent / KOH / methanol / 18 h / Heating View Scheme

sodium hydride in N,N-dimethyl-formamide T=110°C;

1: 74 percent / NaH / dimethylformamide / 110 °C 2: TiCl4 / toluene / 0.5 h / 110 °C View Scheme

1: 74 percent / NaH / dimethylformamide / 110 °C 2: TiCl4 / toluene / 0.5 h / 110 °C View Scheme

<b>With</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '103233', constants.ctx, '0')">pyridine</a>&nbsp;<b>in</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '1730800', constants.ctx, '0')">dichloromethane</a> <br />T=20&deg;C;&nbsp;16&nbsp;h;&nbsp;<br /> &nbsp;