2-叔丁基-4-氯-5-硝基嘧啶合成路线 （共 4 条）
反应条件
1: aq. NH3 / 0 deg C - RT 2: H2 / 5percent Pd/C / methanol / Ambient temperature View Scheme
参考文献
Tielemans, Michel; Christophe, Daniel; Promel, Robert
Journal of Heterocyclic Chemistry, 1987 , vol. 24, p. 705 - 708
反应条件
trichlorophosphate
5 h; Heating / reflux;
参考文献
Sunesis Pharmaceuticals, Inc.
Patent: US2009/36419 A1, 2009 ;
Location in patent: Page/Page column 89; 90 ;
US 20090036419 A1
反应条件
1: 86 percent / aq. NaOH / Ambient temperature; overnight
2: 92 percent / KNO3, H2SO4 conc. / 8 h / 115 °C
3: POCl3 / 1) reflux, 3 h, 2) RT, overnight
View Scheme
参考文献
Tielemans, Michel; Christophe, Daniel; Promel, Robert
Journal of Heterocyclic Chemistry, 1987 , vol. 24, p. 705 - 708
反应条件
1: 92 percent / KNO3, H2SO4 conc. / 8 h / 115 °C
2: POCl3 / 1) reflux, 3 h, 2) RT, overnight
View Scheme
参考文献
Tielemans, Michel; Christophe, Daniel; Promel, Robert
Journal of Heterocyclic Chemistry, 1987 , vol. 24, p. 705 - 708
