1: N,N-dimethyl-formamide With trichlorophosphate in chloroform T=0 - 5°C; Vilsmeier formylation; 2: 6-(4-fluorophenyl)imidazo[2,1-b][1,3]thiazole in chloroform T=20°C; Vilsmeier formylation; Reflux; 3: With water Vilsmeier formylation; Cooling with ice;

1: in ethanol 16 h; Heating / reflux; 2: With ammonia in ethanol; water Alkaline conditions;

in ethanol 16 h; Reflux;

1: 79 percent / tetrahydrofuran / 24 h / 50 °C 2: 87 percent / methanol / 3 h / Heating 3: 84 percent / 2M Na2CO3 / CHCl3 / 0.33 h / 20 °C View Scheme

in ethanol Heating;

hydrogenchloride in water 1 h; Reflux;

1: acetonitrile / Heating 2: 50 percent / ethanol / Heating View Scheme