4-羟基-2(1H)-喹啉酮合成路线 （共 93 条）
反应条件
1: 98 percent / aq. HNO3 / 1.) RT, 10 min, 2.) 75 deg C, 12 min 2: 67 percent / POCl3, benzyltriethylammonium chloride / acetonitrile / 1.) 40 deg C, 30 min, 2.) reflux, 0.3 h 3: 59 percent / Et3N / ethanol / 2.5 h / 50 °C View Scheme
参考文献
Dolle; Fan; Chi Hung Nguyen; Aubertin; Kirn; Andreola; Jamieson; Tarrago-Litvak; Bisagni
Journal of Medicinal Chemistry, 1995 , vol. 38, # 23 p. 4679 - 4686
反应条件
thionyl chloride in 1,4-dioxane Pummerer Sulfoxide Rearrangement; 1.5 h; Reflux;
参考文献
Tetrahedron, , vol. 69, # 2 p. 492 - 499
反应条件
phosphorus oxytribromide
参考文献
Reisch, Johannes; Gunaherath, G. M. Kamal B.
Journal of Heterocyclic Chemistry, 1993 , vol. 30, # 4 p. 1057 - 1060
反应条件
PPA
6 h; 120-140 deg C;
参考文献
Balasubramanian, C.; Kumaraswami, K.; Dharmaraj, N.; Mohan, P. S.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1993 , vol. 32, # 4 p. 460 - 462
反应条件
silver nitrate; 1,8-diazabicyclo[5.4.0]undec-7-ene in dimethyl sulfoxide
T=60°C; P=750.075 Torr; 24 h; Schlenk technique;
参考文献
Ishida, Tomonobu; Kikuchi, Satoshi; Yamada, Tohru
Organic Letters, 2013 , vol. 15, # 14 p. 3710 - 3713
反应条件
in N,N-dimethyl-formamide
T=135°C; 0.05 h; microwave irradiation;
参考文献
Arya, Kapil; Agarwal, Manish
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 1 p. 86 - 93
参考文献
Pandey, G.; Muralikrishna, C.; Bhalerao, U. T.
Tetrahedron, 1989 , vol. 45, p. 6867 - 6874
反应条件
water in acetone
T=20°C; 24 h;
参考文献
Abd El-Nabi, Hisham A.
Organic Preparations and Procedures International, 1997 , vol. 29, # 2 p. 211 - 214
反应条件
sodium hydride in toluene
T=100°C; 2 h;
参考文献
Jung; Park
Synthetic Communications, 2001 , vol. 31, # 8 p. 1195 - 1200
反应条件
sodium hydride in toluene
T=100°C; 2 h;
参考文献
Jung; Park
Synthetic Communications, 2001 , vol. 31, # 8 p. 1195 - 1200
