4-羟基-2(1H)-喹啉酮合成路线 （共 93 条）
反应条件
1: benzene
2: hydriodic acid
View Scheme
参考文献
Gabriel
Chemische Berichte, 1918 , vol. 51, p. 1509
反应条件
phosphorus; hydrogen iodide
参考文献
Gabriel; Gerhard
Chemische Berichte, 1921 , vol. 54, p. 1070
反应条件
acetic acid ester; sodium
und Behandeln des Reaktionsprodukts mit verd.Salzsaeure;
参考文献
Erdmann,H.
Chemische Berichte, 1899 , vol. 32, p. 3570
参考文献
Schoepf et al.
Chemische Berichte, 1956 , vol. 89, p. 2877,2885
反应条件
sodium hydroxide; N-benzyl-N,N,N-triethylammonium chloride in toluene
T=50°C; 4 h; Further byproducts given;
参考文献
Reisch; Mueller; Mester
1981 , vol. 36, # 9 p. 1176 - 1179
反应条件
sodium hydroxide; N-benzyl-N,N,N-triethylammonium chloride in toluene
T=50°C; 4 h; Further byproducts given;
参考文献
Reisch; Mueller; Mester
1981 , vol. 36, # 9 p. 1176 - 1179
反应条件
di-isopropyl azodicarboxylate; triphenylphosphine in tetrahydrofuran
T=0 - 20°C; Mitsunobu reaction;
参考文献
Cravotto, Giancarlo; Nano, Gian Mario; Palmisano, Giovanni; Tagliapietra, Silvia
Heterocycles, 2003 , vol. 60, # 6 p. 1351 - 1358
反应条件
sodium hydroxide; N-benzyl-N,N,N-triethylammonium chloride in toluene
T=50°C; 4 h; Product distribution;
参考文献
Reisch; Mueller; Mester
1981 , vol. 36, # 9 p. 1176 - 1179
反应条件
triethylamine; Methanesulfonyl azide in ethanol
T=20°C; Substitution; 12 h;
参考文献
Pirrung, Michael C.; Blume, Florian
Journal of Organic Chemistry, 1999 , vol. 64, # 10 p. 3642 - 3649
反应条件
potassium carbonate in acetone
240 h; Heating;
参考文献
Grundon Michael F.; Ramachandran, V. N.; Donnelly, Michael E.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1981 , p. 633 - 635
