4-羟基-2(1H)-喹啉酮合成路线 （共 93 条）
反应条件
N,N-dimethyl-aniline in toluene
T=80 - 95°C;
参考文献
Noehammer,G.; Kappe,T.
Monatshefte fuer Chemie, 1976 , vol. 107, p. 859 - 863
反应条件
N,N-dimethyl-aniline in toluene
T=90°C;
参考文献
Noehammer,G.; Kappe,T.
Monatshefte fuer Chemie, 1976 , vol. 107, p. 859 - 863
反应条件
1: PhNMe2 / toluene / 80 - 95 °C
2: (thermolysis)
View Scheme
参考文献
Noehammer,G.; Kappe,T.
Monatshefte fuer Chemie, 1976 , vol. 107, p. 859 - 863
参考文献
Noehammer,G.; Kappe,T.
Monatshefte fuer Chemie, 1976 , vol. 107, p. 859 - 863
反应条件
sodium hydroxide; N-benzyl-N,N,N-triethylammonium chloride in toluene
T=50°C; 4 h; Further byproducts given;
参考文献
Reisch; Mueller; Mester
1981 , vol. 36, # 9 p. 1176 - 1179
反应条件
sodium hydroxide; N-benzyl-N,N,N-triethylammonium chloride in toluene
T=50°C; 4 h; Product distribution;
参考文献
Reisch; Mueller; Mester
1981 , vol. 36, # 9 p. 1176 - 1179
反应条件
silver carbonate in benzene
T=20°C; 72 h;
参考文献
Morel, Ademir Farias; Larghi, Enrique L.; Selvero, Marcel Manke
Synlett, 2005 , # 18 art. no. S07105ST, p. 2755 - 2758
反应条件
potassium hydroxide in acetone
2 h; Heating; Yields of byproduct given;
参考文献
Reisch, Johannes; Mester, Iuliu
Archiv der Pharmazie (Weinheim, Germany), 1980 , vol. 313, # 9 p. 751 - 755
反应条件
water
T=80°C; Domino Knoevenagel/6π-electrocyclization; 6 h;
参考文献
Jung, Ene Jin; Park, Byung Ho; Lee, Yong Rok
Green Chemistry, 2010 , vol. 12, # 11 p. 2003 - 2011
反应条件
sodium hydroxide; N-benzyl-N,N,N-triethylammonium chloride in toluene
T=50°C; 88 h; MechanismProduct distribution;
参考文献
Reisch, Johannes; Bathe, Andreas; Salehi-Artimani, Reza A.
Archiv der Pharmazie (Weinheim, Germany), 1986 , vol. 319, # 8 p. 720 - 727
