1: ethanol; H2O / 10 h / Heating 2: sulphuric acid / H2O / 3 h / Heating 3: 17.2 g / silphuric acid / 1,2-dichloro-ethane / 5 h / Heating View Scheme
参考文献
Holla, B. Shivarama; Prasanna; Poojary, Boja; Rao; Shridhara; Bhat, U. Ganesha
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2004 , vol. 43, # 4 p. 864 - 868
1: malonic acid dimethyl ester With triethylamine; magnesium chloride in toluene T=25°C; 1 h; 2: 2-chloro-5-chloromethyl-pyridine in toluene 1 h; 3: With water in dimethyl sulfoxide T=165°C; 2 h;
Loso, Michael R.; Nugent, Benjamin M.; Zhu, Yuanming; Rogers, Richard B.; Huang, Jim X.; Renga, James M.; Whiteker, Gregory T.; Breaux, Nneka T.; Daeuble, John F.
Patent: US2008/108666 A1, 2008 ;
Location in patent: Page/Page column 7-8 ;
1: With sodium hydroxide in N,N-dimethyl-formamide T=50°C; 8 h; 2: With hydrogenchloride in water; N,N-dimethyl-formamide pH=4; Product distribution / selectivity;
参考文献
EXCEL CROP CARE LIMITED
Patent: US2007/197792 A1, 2007 ;
Location in patent: Page/Page column 2 ;
