1-甲基-4-(4-硝基苯)哌嗪合成路线 （共 9 条）
反应条件
sodium tetrahydroborate; acetic acid in chloroform T=0 - 20°C; 13 h;
参考文献
Koroleva; Gusak; Ermolinskaya; Ignatovich
Russian Journal of Organic Chemistry, 2013 , vol. 49, # 4 p. 563 - 567
Zh. Org. Khim., 2013 , vol. 49, # 4 p. 580 - 584
反应条件
potassium carbonate in acetone 46 h; Heating;
参考文献
Biagi; Dell'Omodarme; Ferretti; Giorgi; Livi; Scartoni
Farmaco, 1992 , vol. 47, # 3 p. 335 - 344
反应条件
triethylamine in dichloromethane Heating;
参考文献
Mai, Antonello; Sbardella, Gianluca; Artico, Marino; Massa, Silvio; Lampis, Giorgio; Deidda, Delia; Pompeit, Raffaello
Medicinal Chemistry Research, 1999 , vol. 9, # 3 p. 149 - 161
反应条件
1: 4-nitrobenzaldehdye With sodium tris(acetoxy)borohydride in dichloromethane T=0°C; 0.166667 h; 2: 1-methyl-piperazine in dichloromethane T=0 - 20°C; 4 h;
参考文献
WO2006/88949 A1, ;
Page/Page column 178-180 ;
参考文献
Boehringer Ingelheim Pharma GmbH and Co. KG
Patent: US6794395 B1, 2004 ;
Location in patent: Page/Page column 23 ;
反应条件
C52H67ClFeNPPd; caesium carbonate in tetrahydrofuran; water T=80°C; Suzuki-Miyaura cross-coupling; 12 h;
参考文献
Zou, Dapeng; Cui, Hongmeng; Qin, Lijin; Li, Jingya; Wu, Yangjie; Wu, Yusheng
Synlett, 2011 , # 3 art. no. S05710ST, p. 349 - 356
反应条件
C52H67ClFeNPPd; caesium carbonate in tetrahydrofuran; water T=80°C; Suzuki-Miyaura cross-coupling; 12 h;
参考文献
Zou, Dapeng; Cui, Hongmeng; Qin, Lijin; Li, Jingya; Wu, Yangjie; Wu, Yusheng
Synlett, 2011 , # 3 art. no. S05710ST, p. 349 - 356
反应条件
1: 1-methyl-piperazine With formic acid 0.25 h; cooling; 2: 4-nitrobenzaldehdye T=180 - 200°C; Leuckart-Wallach reaction; 8 h; Further stages.;
参考文献
Ignatovich; Gusak; Chernikhova; Kozlov; Koroleva
Chemistry of Heterocyclic Compounds, 2007 , vol. 43, # 12 p. 1540 - 1543
反应条件
platinum(IV) oxide; hydrogen in ethanol P=2585.81 Torr; 16 h;
参考文献
European Journal of Medicinal Chemistry, , vol. 46, # 7 p. 2917 - 2929
