4-氯-2,6-二甲基吡啶-3-羧酸乙酯合成路线 （共 12 条）
反应条件
trichlorophosphate; benzene
参考文献
Justus Liebigs Annalen der Chemie, , vol. 366, p. 405
Chemische Berichte, , vol. 34, p. 2286
Chemische Berichte, , vol. 35, p. 3158
反应条件
1: NH3 2: benzene; phosphorus oxychloride View Scheme
参考文献
Justus Liebigs Annalen der Chemie, , vol. 366, p. 405
参考文献
Journal of the Chemical Society, , vol. 59, p. 183
Journal of the Chemical Society, , vol. 77, p. 971
参考文献
Journal of the Chemical Society, , vol. 59, p. 183
Journal of the Chemical Society, , vol. 77, p. 971
反应条件
1: palladium/CaCO3; methanol / Hydrogenation 2: lithium alanate; diethyl ether / und anschliessenden Erwaermen. 3: thionyl chloride 4: palladium/calcium carbonate; methanol / Hydrogenation View Scheme
参考文献
Tsuda et al.
Pharmaceutical Bulletin, 1953 , vol. 1, p. 122,125
反应条件
hydrogenchloride T=150°C;
参考文献
Michaelis; Hanisch
Chemische Berichte, 1902 , vol. 35, p. 3158
参考文献
Michaelis
Justus Liebigs Annalen der Chemie, 1909 , vol. 366, p. 405
反应条件
formic acid; triethylamine; palladium on activated charcoal below 85 deg C, reflux at 95 deg C, 6 days;
参考文献
Tetrahedron, , vol. 39, # 12 p. 2001 - 2008
反应条件
methanol; Lindlar's catalyst Hydrogenation;
参考文献
Sperber et al.
Journal of the American Chemical Society, 1959 , vol. 81, p. 704,707
反应条件
1: palladium/CaCO3; methanol / Hydrogenation
2: lithium alanate; diethyl ether / und anschliessenden Erwaermen.
3: thionyl chloride
View Scheme
参考文献
Tsuda et al.
Pharmaceutical Bulletin, 1953 , vol. 1, p. 122,125
