1-(2-羟基-6-甲氧基苯基)乙基-1-酮合成路线 （共 45 条）
反应条件
1: With sodium hydroxide; dipotassium peroxodisulfate in water T=20°C; 2: With hydrogenchloride; sodium sulfite in water 2 h; Heating / reflux;
参考文献
ECOBIOTICS LIMITED
Patent: WO2007/70986 A1, 2007 ;
Location in patent: Page/Page column 17; 44; 46-47 ;
反应条件
1: sodium 2: aluminium chloride / 150 °C View Scheme
参考文献
Desai; Sethna
Journal of Organic Chemistry, 1957 , vol. 22, p. 388
反应条件
1: methanol / 1 h / 160 °C 2: sodium ethanolate / ethanol / 0.42 h / 80 °C / |Microwave irradiation 3: N,N-dimethyl-formamide / 3 h / 140 °C / |Microwave irradiation 4: potassium hydroxide / water; tetrahydrofuran / 2 h / 120 °C / |Microwave irradiation 5: N-ethyl-N,N-diisopropylamine; 2,6-dimethylpyridine; bis(trichloromethyl) carbonate / dichloromethane / 18 h / 20 °C 6: QP-SA / dichloromethane / 20 h / 18 °C View Scheme
参考文献
Battilocchio, Claudio; Deadman, Benjamin J.; Nikbin, Nikzad; Kitching, Matthew O.; Baxendale, Ian R.; Ley, Steven V.
Chemistry - A European Journal, 2013 , vol. 19, # 24 p. 7917 - 7930
反应条件
potassium carbonate in N,N-dimethyl-formamide T=30 - 35°C; Product distribution / selectivity;
参考文献
Farouz, Francine S.; Holcomb, Ryan Coatsworth; Kasar, Ramesh; Myers, Steven Scott
Patent: US2011/144126 A1, 2011 ;
Location in patent: Page/Page column 12 ;
US 20110144126 A1
反应条件
2: t-BuOK
3: HCl
View Scheme
参考文献
Stubbing, Louise A.; Li, Freda F.; Furkert, Daniel P.; Caprio, Vittorio E.; Brimble, Margaret A.
Tetrahedron, 2012 , vol. 68, # 34 p. 6948 - 6956
参考文献
LG Chemical, Ltd.
Patent: US6500846 B1, 2002 ;
反应条件
1: HNO3 / acetic acid
2: Br2
View Scheme
参考文献
Krause,G.H.; Hoyer,H.
Zeitschrift fuer Naturforschung, Teil B: Anorganische Chemie, Organische Chemie, Biochemie, Biophysik, Biologie, 1972 , vol. 27, p. 663 - 674
反应条件
1: aq. NaOH solution; aqueous .K2S2O8 / Erhitzen des Reaktionsloesung mit wss.HCl oder wss.H2SO4
2: sodium benzoate / 200 °C / Erwaermen des Reaktionsprodukts mit wss.-aethanol. Kalilauge
View Scheme
参考文献
Nakazawa
Yakugaku Zasshi, 1939 , vol. 59, p. 524,527; dtsch. Ref. S. 199, 200
Chem.Abstr., 1940 , p. 1017
反应条件
1: KOH / methanol / 20 °C
2: I2 / dimethylsulfoxide / Heating
3: 83 percent / AlCl3 / CH2Cl2 / 20 °C
View Scheme
参考文献
Dao, Tran Thanh; Chi, Yeon Sook; Kim, Jeongsoo; Kim, Hyun Pyo; Kim, Sanghee; Park, Haeil
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 5 p. 1165 - 1167
反应条件
1: KOH / methanol / 20 °C
2: I2 / dimethylsulfoxide / Heating
View Scheme
参考文献
Dao, Tran Thanh; Chi, Yeon Sook; Kim, Jeongsoo; Kim, Hyun Pyo; Kim, Sanghee; Park, Haeil
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 5 p. 1165 - 1167
