1-(2-羟基-6-甲氧基苯基)乙基-1-酮合成路线 （共 45 条）
反应条件
1: aq. NaOH solution; aqueous .K2S2O8 / Erhitzen des Reaktionsloesung mit wss.HCl oder wss.H2SO4
2: sodium benzoate / 200 °C / Erwaermen des Reaktionsprodukts mit wss.-aethanol. Kalilauge
3: aq.-ethanolic KOH-solution
View Scheme
参考文献
Baker
Journal of the Chemical Society, 1939 , p. 956,959
反应条件
sodium hydroxide in ethanol
Claisen Schmidt condensation;
参考文献
Devakaram, Ruth; Black, David Stc.; Kumar, Naresh
Tetrahedron Letters, 2010 , vol. 51, # 28 p. 3636 - 3638
反应条件
sodium hydroxide; tetrabutyl-ammonium chloride
1.) water, dichloromethane, r.t., 10 min; 2.) r.t., 5 h; Yield given. Multistep reaction;
参考文献
Lim, Soon Sung; Jung, Sang Hoon; Ji, Jun; Shin, Kuk Hyun; Keum, Sam Rok
Journal of Pharmacy and Pharmacology, 2001 , vol. 53, # 5 p. 653 - 668
反应条件
1: 78 percent / POCl2 / pyridine / 3 h / 60 - 70 °C
2: 77 percent / NaH / tetrahydrofuran / 5 h / Heating
3: 60 percent / acetic acid; sulfuric acid / 6 h / 80 - 90 °C
View Scheme
参考文献
Barros, Ana I. R. N. A.; Silva, Artur M. S.
Monatshefte fur Chemie, 2006 , vol. 137, # 12 p. 1505 - 1528
反应条件
1: 87 percent / POCl2 / pyridine / 3 h / 60 - 70 °C
2: 80 percent / NaH / tetrahydrofuran / 2.5 h / Heating
3: 72 percent / iodine / 3 h / 80 - 90 °C
View Scheme
参考文献
Barros, Ana I. R. N. A.; Silva, Artur M. S.
Monatshefte fur Chemie, 2006 , vol. 137, # 12 p. 1505 - 1528
反应条件
1: 54 percent / POCl2 / pyridine / 3 h / 60 - 70 °C
2: 60 percent / NaH / tetrahydrofuran / 3.5 h / Heating
3: 82 percent / p-toluenesulfonic acid / dimethylsulfoxide / 80 - 90 °C
View Scheme
参考文献
Barros, Ana I. R. N. A.; Silva, Artur M. S.
Monatshefte fur Chemie, 2006 , vol. 137, # 12 p. 1505 - 1528
反应条件
sodium
T=0 - 100°C; 3.5 h;
参考文献
Griffin, Roger J.; Fontana, Gabriele; Golding, Bernard T.; Guiard, Sophie; Hardcastle, Ian R.; Leahy, Justin J. J.; Martin, Niall; Richardson, Caroline; Rigoreau, Laurent; Stockley, Martin; Smith, Graeme C. M.
Journal of Medicinal Chemistry, 2005 , vol. 48, # 2 p. 569 - 585
反应条件
1: 71 percent / EtONa / ethanol / 10 h / 100 °C
2: 90 percent / aq. NaHCO3 / 3 h / 80 °C
3: 87 percent / HBr; AcOH / 2 h / 100 °C
View Scheme
参考文献
Hadjeri, Mohamed; Barbier, Magali; Ronot, Xavier; Mariotte, Anne-Marie; Boumendjel, Ahcene; Boutonnat, Jean
Journal of Medicinal Chemistry, 2003 , vol. 46, # 11 p. 2125 - 2131
反应条件
sodium ethanolate
T=100°C; 16 h;
参考文献
HANMI PHARM. CO., LTD.
Patent: WO2005/33101 A1, 2005 ;
Location in patent: Page/Page column 16-17 ;
WO 2005/033101 A1
反应条件
1: 71 percent / EtONa / ethanol / 10 h / 100 °C
2: 90 percent / aq. NaHCO3 / 3 h / 80 °C
View Scheme
参考文献
Hadjeri, Mohamed; Barbier, Magali; Ronot, Xavier; Mariotte, Anne-Marie; Boumendjel, Ahcene; Boutonnat, Jean
Journal of Medicinal Chemistry, 2003 , vol. 46, # 11 p. 2125 - 2131
