1-(2-羟基-6-甲氧基苯基)乙基-1-酮合成路线 （共 45 条）
反应条件
sodium ethanolate in ethanol
1 h; Heating;
参考文献
MERCK PATENT GMBH
Patent: WO2006/94601 A1, 2006 ;
Location in patent: Page/Page column 62 ;
反应条件
1: With sodium hydride
T=0°C; 3.5 h; Inert atmosphere;
2: With hydrogenchloride in methanol; water
T=0 - 20°C; Inert atmosphere;
参考文献
Stubbing, Louise A.; Li, Freda F.; Furkert, Daniel P.; Caprio, Vittorio E.; Brimble, Margaret A.
Tetrahedron, 2012 , vol. 68, # 34 p. 6948 - 6956
反应条件
nitric acid; acetic acid
1.) RT, 40 min, 2.) from 45 to 50 deg C, 16 h;
参考文献
Cushman, Mark; Zhu, Helen; Geahlen, Robert L.; Kraker, Alan J.
Journal of Medicinal Chemistry, 1994 , vol. 37, # 20 p. 3353 - 3362
反应条件
1: AlCl3; diethyl ether; HCl / Erwaermen des Reaktionsprodukts mit Wasser
2: aq. NaOH solution; aqueous H2O2
3: sodium benzoate / 180 °C
4: concentrated sulfuric acid
5: aluminium chloride; nitrobenzene
View Scheme
参考文献
Nakazawa
Yakugaku Zasshi, 1939 , vol. 59, p. 524,527; dtsch. Ref. S. 199, 200
Chem.Abstr., 1940 , p. 1017
反应条件
1: 50percent sodium hydroxide / ethanol; H2O / 350 h / 20 °C
2: H2O; dioxane / 30 °C / pH range: 8-11, equilibrium
View Scheme
参考文献
Old, K. Barry; Main, Lyndsay
Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), 1982 , p. 1309 - 1312
