5-溴-2-(三氟甲基)苯胺合成路线 （共 4 条）
反应条件
iron; ammonium chloride in tetrahydrofuran; ethanol; water T=80°C; 1 h;
参考文献
ELAN PHARMACEUTICALS, INC.; SHAM, Hing, L.; KONRADI, Andrei, W.; HOM, Roy, K.; PROBST, Gary, D.; BOWERS, Simeon; TRUONG, Anh; NEITZ, R., Jeffrey; SEALY, Jennifer; TOTH, Gergely
Patent: WO2010/91310 A1, 2010 ;
Location in patent: Page/Page column 100 ;
WO 2010/091310 A1
反应条件
[iridium(III)(2-phenylpyridine)3] in N,N-dimethyl-formamide T=20°C; Inert atmosphereIrradiationSchlenk technique; Overall yield = 65 percent; regioselective reaction;
参考文献
Organic Letters, , vol. 16, # 6 p. 1768 - 1771
反应条件
1: With tert.-butylnitrite; boron trifluoride diethyl etherate in tetrahydrofuran T=-78 - 20°C; 0.666667 h; 2: With iodine; potassium iodide in acetone T=0 - 20°C; 1 h;
参考文献
LEO PHARMA A/S
Patent: US2012/129926 A1, 2012 ;
Location in patent: Page/Page column 21 ;
反应条件
1: With sulfuric acid; iron(II) sulfate T=120°C; 4 h; 2: With water; sodium hydroxide in ethanol; ethyl acetate; nitrobenzene T=20°C; pH=13;
参考文献
ELAN PHARMACEUTICALS, INC.; SHAM, Hing, L.; KONRADI, Andrei, W.; HOM, Roy, K.; PROBST, Gary, D.; BOWERS, Simeon; TRUONG, Anh; NEITZ, R., Jeffrey; SEALY, Jennifer; TOTH, Gergely
Patent: WO2010/91310 A1, 2010 ;
Location in patent: Page/Page column 101 ;
WO 2010/091310 A1
