3-苯基-3,4-二氢-2H-1,4-苯并恶嗪合成路线 （共 6 条）
反应条件
3,3'-diphenyl-BINOL-phosphate; diethyl-1,4-dihydro-2,6-dimethyl-3,5-pyridine dicarboxylate in chloroform
T=20°C; 72 h; enantioselective reaction;
参考文献
Zhang, Zhuxiu; Ji, Young Ran; Wojtas, Lukasz; Gao, Wen-Yang; Ma, Shengqian; Zaworotko, Michael J.; Antilla, Jon C.
Chemical Communications, 2013 , vol. 49, # 70 p. 7693 - 7695
反应条件
sodium hypophosphite; palladium 10 on activated carbon in tetrahydrofuran; water
T=20°C; 36 h;
参考文献
IONIX PHARMACEUTICALS LIMITED
Patent: WO2005/5392 A1, 2005 ;
Location in patent: Page 70 ;
WO 2005/005392 A1
反应条件
1.1: O3 / methanol; CH2Cl2 / -78 °C
1.2: Me2S; p-CH3C6H4SO3H / methanol; CH2Cl2 / -78 - 20 °C
1.3: 98 percent / amberlyst-15 / acetone / 20 °C
2.1: 76 percent / H2 / Pd/C / methanol; tetrahydrofuran / 25 °C / 3040 Torr
View Scheme
参考文献
Bunce, Richard A.; Herron, Derrick M.; Hale, Lu Y.
Journal of Heterocyclic Chemistry, 2003 , vol. 40, # 6 p. 1031 - 1039
反应条件
1: tetrabutylammomium bromide; potassium carbonate / water; dichloromethane / 8 h / 20 - 40 °C
2: (R)-(-)-1,1'-binaphthyl-2,2'-diyl hydrogen phosphate; di-isopropyl 1,4-dihydro-2,6-dimethylpyridine-3,5-dicarboxylate / chloroform-d1 / 0.5 h
View Scheme
参考文献
Chen, Zhang-Pei; Chen, Mu-Wang; Guo, Ran-Ning; Zhou, Yong-Gui
Organic Letters, 2014 , vol. 16, # 5 p. 1406 - 1409
反应条件
1: tetrabutylammomium bromide; potassium carbonate / water; dichloromethane / 8 h / 20 - 40 °C
2: (R)-(-)-1,1'-binaphthyl-2,2'-diyl hydrogen phosphate; di-isopropyl 1,4-dihydro-2,6-dimethylpyridine-3,5-dicarboxylate / chloroform-d1 / 0.5 h
View Scheme
参考文献
Chen, Zhang-Pei; Chen, Mu-Wang; Guo, Ran-Ning; Zhou, Yong-Gui
Organic Letters, 2014 , vol. 16, # 5 p. 1406 - 1409
反应条件
1: potassium carbonate / acetone / 16 h / 20 °C
2: palladium 10 on activated carbon; hydrogen / tetrahydrofuran; methanol / 20 °C / 3040.2 Torr
View Scheme
参考文献
Baraldi, Pier Giovanni; Saponaro, Giulia; Moorman, Allan R.; Romagnoli, Romeo; Preti, Delia; Baraldi, Stefania; Ruggiero, Emanuela; Varani, Katia; Targa, Martina; Vincenzi, Fabrizio; Borea, Pier Andrea; Aghazadeh Tabrizi, Mojgan
Journal of Medicinal Chemistry, 2012 , vol. 55, # 14 p. 6608 - 6623
