trifluorormethanesulfonic acid in 1,4-dioxane T=120°C; 12 h;

1: With sodium hexamethyldisilazane in tetrahydrofuran; N,N-dimethyl-formamide T=-10°C; Claisen condensation; 3.5 h; Inert atmosphere; 2: With potassium dihydrogenphosphate; copper(l) iodide; K3PO4*7H2O in tetrahydrofuran; N,N-dimethyl-formamide T=110°C; 6 h; Inert atmosphere;

1: potassium carbonate / N,N-dimethyl-formamide / 12 h / 20 °C / |Inert atmosphere 2: trifluorormethanesulfonic acid / 1,4-dioxane / 12 h / 120 °C View Scheme

1: potassium carbonate / N,N-dimethyl-formamide / 12 h / 20 °C / |Inert atmosphere 2: trifluorormethanesulfonic acid / 1,4-dioxane / 12 h / 120 °C View Scheme

potassium hydroxide in isopropyl alcohol Heating;

sodium hydride

(i) Br2, (ii) NaOAc, AcOH, (iii) aq. KOH; Multistep reaction;