3-(4-哌啶基)-1-丙醇合成路线 （共 11 条）
反应条件
hydrogen; palladium on activated charcoal in acetic acid P=2585.7 Torr; 48 h;
参考文献
Egbertson, Melissa S.; Chang, Charles T.-C.; Duggan, Mark E.; Gould, Robert J.; Halczenko, Wasyl; et al.
Journal of Medicinal Chemistry, 1994 , vol. 37, # 16 p. 2537 - 2551
反应条件
1: With lithium aluminium tetrahydride in tetrahydrofuran T=0°C; 6 h; 2: With potassium hydroxide in tetrahydrofuran; water 14 h;
参考文献
EP1553074 A1, ;
Page/Page column 80-81 ;
反应条件
hydrogenchloride in 1,4-dioxane; dichloromethane
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 22, # 15 p. 5123 - 5128
反应条件
1: 96 percent / triethylamine / CH2Cl2 / 1.33 h / -0.1 °C 2: 76 percent / phosphorus tribromide / CH2Cl2 / 16 h / Ambient temperature 3: 1.) PCl5, 2.) liquid NH3 / 1.) 25 - 200 deg C, 2.) methanol, 393 K, 2.5 h, bomb View Scheme
参考文献
Ruggles, Christopher J.; Halpern, Arthur M.
Journal of the American Chemical Society, 1988 , vol. 110, # 17 p. 5692 - 5698
反应条件
formic acid; water T=140°C;
参考文献
Cesco-Cancian, Sergio; Chen, Hongfeng; Grimm, Jeffrey S.; Mani, Neelakandha S.; Mapes, Christopher M.; Palmer, David C.; Pippel, Daniel J.; Sorgi, Kirk L.; Xiao, Tong
Patent: US2010/4450 A1, 2010 ;
Location in patent: Page/Page column 14 ;
反应条件
1.1: 92 percent / 1N NaOH / dioxane 2.1: 95 percent / (COCl)2; DMSO / CH2Cl2 / -78 °C 3.1: 40 percent / tetrahydrofuran 4.1: BH3*THF 4.2: 90 percent / H2O2; NaOH 5.1: 80 percent / CBr4; PPh3 / CH2Cl2 View Scheme
参考文献
Song, Xiaoping; He, Henry T.; Siahaan, Teruna J.
Organic Letters, 2002 , vol. 4, # 4 p. 549 - 552
反应条件
1.1: 92 percent / 1N NaOH / dioxane 2.1: 95 percent / (COCl)2; DMSO / CH2Cl2 / -78 °C 3.1: 40 percent / tetrahydrofuran 4.1: BH3*THF 4.2: 90 percent / H2O2; NaOH View Scheme
参考文献
Song, Xiaoping; He, Henry T.; Siahaan, Teruna J.
Organic Letters, 2002 , vol. 4, # 4 p. 549 - 552
反应条件
1: 92 percent / 1N NaOH / dioxane 2: 95 percent / (COCl)2; DMSO / CH2Cl2 / -78 °C View Scheme
参考文献
Song, Xiaoping; He, Henry T.; Siahaan, Teruna J.
Organic Letters, 2002 , vol. 4, # 4 p. 549 - 552
反应条件
1: 73 percent / NaOH / dioxane / 18 h 2: 78 percent / imidazol, I2, triphenylphosphine chloride / toluene / 1.5 h View Scheme
参考文献
Ashford, Mark E.; Nguyen, Vu H.; Greguric, Ivan; Pham, Tien Q.; Keller, Paul A.; Katsifis, Andrew
Organic and Biomolecular Chemistry, 2014 , vol. 12, # 5 p. 783 - 794
反应条件
triethylamine in dichloromethane T=-0.1°C; 1.33333 h;
参考文献
Ruggles, Christopher J.; Halpern, Arthur M.
Journal of the American Chemical Society, 1988 , vol. 110, # 17 p. 5692 - 5698
