5-(2-噻吩基)-1,3-噁唑合成路线 （共 7 条）
反应条件
potassium carbonate in methanol T=66°C; 4 h; Inert atmosphere;
参考文献
Li, Bryan; Buzon, Richard A.; Zhang, Zhijun; Koshiba, Takahiro; Fukuyama, Tohru
Organic Syntheses, 2010 , vol. 87, p. 16 - 25
反应条件
potassium carbonate in methanol 5 h; Heating / reflux;
参考文献
AVENTIS PHARMACEUTICALS INC.
Patent: WO2005/40142 A1, 2005 ;
Location in patent: Page/Page column 35-36 ;
WO 2005/040142 A1
反应条件
potassium carbonate in methanol T=55°C; 16 h;
参考文献
Chen, Bang-Chi; Bednarz, Mark S.; Zhang, Huiping; Zhao, Rulin; Murali; Balu Balasubramanian, Dhar; Barrish, Joel C.
Heterocycles, 2006 , vol. 68, # 1 p. 167 - 173
反应条件
potassium tert-butylate in tetrahydrofuran 2 h; Ambient temperature;
参考文献
Sasaki, Hideaki
Chemical and Pharmaceutical Bulletin, 1997 , vol. 45, # 8 p. 1369 - 1371
反应条件
1,8-diazabicyclo[5.4.0]undec-7-ene in toluene T=80°C; 4 h;
参考文献
Synlett, , # 2 p. 302 - 305
反应条件
1: With lithium hexamethyldisilazane in tetrahydrofuran; N,N-dimethyl-formamide
T=-70 - -15°C; 0.5 h;
2: With N-bromosuccinmide in tetrahydrofuran; N,N-dimethyl-formamide
T=-60°C; 0.5 h;
参考文献
Li, Bryan; Buzon, Richard A.; Zhang, Zhijun
Organic Process Research and Development, 2007 , vol. 11, # 6 p. 951 - 955
反应条件
1.1: lithium hexamethyldisilazane / N,N-dimethyl-formamide / -15 - -10 °C / Inert atmosphere
1.2: -78 - -65 °C / Inert atmosphere
2.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride
View Scheme
参考文献
Li, Bryan; Buzon, Richard A.; Zhang, Zhijun; Koshiba, Takahiro; Fukuyama, Tohru
Organic Syntheses, 2010 , vol. 87, p. 16 - 25
